ArticleBMC complementary and alternative medicine2015
Investigation of the mechanisms of Angelica dahurica root extract-induced vasorelaxation in isolated rat aortic rings.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Norisoboldine Induces Endothelium-Dependent Vasorelaxation and Attenuates Hypertension by Modulating CaAntioxidants (Basel, Switzerland) · 2026Article
- Vasorelaxant and Blood Pressure-Lowering Effects ofInternational journal of molecular sciences · 2024Article
- Phytochemical Constituents, Folk Medicinal Uses, and Biological Activities of GenusMolecules (Basel, Switzerland) · 2022Review
- Arbuscular mycorrhizal fungi and production of secondary metabolites in medicinal plants.Mycorrhiza · 2022Review
- Study on the vasodilatory activity of lotus leaf extract and its representative substance nuciferine on thoracic aorta in rats.Frontiers in pharmacology · 2022Article
- TheFrontiers in pharmacology · 2022Review
- Secondary Metabolites of Plants as Modulators of Endothelium Functions.International journal of molecular sciences · 2021Review
- Facile and Rapid Isolation of Oxypeucedanin Hydrate and Byakangelicin fromMolecules (Basel, Switzerland) · 2021Article
- Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy.Frontiers in pharmacology · 2021Review
- Imperatorin as a Promising Chemotherapeutic Agent Against Human Larynx Cancer and Rhabdomyosarcoma Cells.Molecules (Basel, Switzerland) · 2020Article
- Thirteen-Week Oral Toxicity Study of HVC1 in Rats.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- The predictive utility of the plant phylogeny in identifying sources of cardiovascular drugs.Pharmaceutical biology · 2018Article
- Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium-induced colitis in mice.British journal of pharmacology · 2018Article
- Vasorelaxant effects of Angelica decursiva root on isolated rat aortic rings.BMC complementary and alternative medicine · 2017Article
- Heartworm extract induces relaxation of isolated rat thoracic aorta.The Journal of veterinary medical science · 2017Article
- Simultaneous Determination of Three Furanocoumarins by UPLC/MS/MS: Application to Pharmacokinetic Study of Angelica dahurica Radix after Oral Administration to Normal and Experimental Colitis-Induced Rats.Molecules (Basel, Switzerland) · 2017Article
- Role of the potassium channels in vasorelaxant effect of asafoetida essential oil.Avicenna journal of phytomedicineArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe root of Angelica dahurica Bentham et Hooker (Umbelliferae) has been used as a traditional medicine for colds, headache, dizziness, toothache, supraorbital pain, nasal congestion, acne, ulcer, carbuncle, and rheumatism in China, Japan, and Korea. Interestingly, it has been used in the treatment of vascular diseases including hypertension. The aim of this study was to provide pharmacological evidence for the anti-hypertensive effect of A. dahurica by investigating the mechanism underlying its vasorelaxant effect.
methodsThe vasorelaxant effects of a 70% methanol extract of the A. dahurica root (ADE) on rat thoracic aorta and its underlying mechanisms were assessed. Isolated rat aortic rings were suspended in organ chambers containing 10 ml Krebs-Henseleit (K-H) solution and placed between 2 tungsten stirrups and connected to an isometric force transducer. Changes in tension were recorded via isometric transducers connected to a data acquisition system.
resultsADE causes concentration-dependent relaxation in both endothelium-intact and endothelium-denuded aortic rings precontracted with phenylephrine (PE; 1 μM) or potassium (KCl; 60 mM) in K-H solution. And pre-treatment with ADE (1 mg/ml) inhibited calcium-induced vasocontraction of aortic rings induced by PE or KCl. However, ADE pre-treatment did not affect the contraction induced by PE or caffeine in Ca(2+)-free K-H solution.
conclusionsThese results suggested that the ADE has vasorelaxant effect and the vasorelaxant activity is mediated by endothelium-independent pathway that includes the blockade of extracellular calcium influx through the receptor-operated Ca(2+) channel and voltage-dependent calcium channel pathways.
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