ArticleBMC cancer2015
Population attributable risks of oral cavity cancer to behavioral and medical risk factors in France: results of a large population-based case-control study, the ICARE study.
Article in BMC cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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18 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- The synergistic effect of tobacco and alcohol consumption on oral squamous cell carcinoma: a systematic review and meta-analysis.Clinical oral investigations · 2019Pooled it
- Diabetes risk reduction diet and the risk of oral and pharyngeal cancer.European journal of nutrition · 2026Observational
- Global, regional and national burden of lip and oral cavity cancer from 1990 to 2021 and projections to 2036.BMC oral health · 2025Article
- Targeted Screening Strategies for Head and Neck Cancer: A Global Review of Evidence, Technologies, and Cost-Effectiveness.Diagnostics (Basel, Switzerland) · 2025Review
- Clinico-pathological specificities of gingival carcinoma among 32 patients with oral cancer: a cross sectional retrospective and observational study.BMC oral health · 2024Observational
- The mortality of oral cancer attributable to tobacco in China, the US, and India.Journal of cancer research and clinical oncology · 2023Article
- Evolution of the Incidence of Oral Cavity Cancers in the Elderly from 1990 to 2018.Journal of clinical medicine · 2023Article
- Head and neck cancer risk factors in the French West Indies.BMC cancer · 2021Article
- Observational
- Compositional Shift of Oral Microbiota Following Surgical Resection of Tongue Cancer.Frontiers in cellular and infection microbiology · 2020Article
- Head and neck cancer prevention: from primary prevention to impact of clinicians on reducing burden.Annals of oncology : official journal of the European Society for Medical Oncology · 2019Review
- Knowledge and Attitudes of Primary Health Care Dentists Regarding Oral Cancer in Brazil.Acta stomatologica Croatica · 2019Article
- Characteristics of the Salivary Microbiota in Patients With Various Digestive Tract Cancers.Frontiers in microbiology · 2019Article
- Patient awareness/knowledge towards oral cancer: a cross-sectional survey.BMC oral health · 2018Article
- Oral cancer associated with chronic mechanical irritation of the oral mucosa.Medicina oral, patologia oral y cirugia bucal · 2018Article
- Role of high-risk human papillomavirus in the etiology of oral and oropharyngeal cancers in Thailand: A case-control study.SAGE open medicine · 2018Article
- Incidence trends for potentially human papillomavirus-related and -unrelated head and neck cancers in France using population-based cancer registries data: 1980-2012.International journal of cancer · 2017Article
- Roles of preoperative C-reactive protein are more relevant in buccal cancer than other subsites.World journal of surgical oncology · 2017Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPopulation attributable risks (PARs) are useful tool to estimate the burden of risk factors in cancer incidence. Few studies estimated the PARs of oral cavity cancer to tobacco smoking alone, alcohol drinking alone and their joint consumption but none performed analysis stratified by subsite, gender or age. Among the suspected risk factors of oral cavity cancer, only PAR to a family history of head and neck cancer was reported in two studies. The purpose of this study was to estimate in France the PARs of oral cavity cancer to several recognized and suspected risk factors, overall and by subsite, gender and age.
methodsWe analysed data from 689 oral cavity cancer cases and 3481 controls included in a population-based case-control study, the ICARE study. Unconditional logistic regression models were used to estimate odds ratios (ORs), PARs and 95% confidence intervals (95% CI).
resultsThe PARs were 0.3% (95% CI -3.9%; +3.9%) for alcohol alone, 12.7% (6.9%-18.0%) for tobacco alone and 69.9% (64.4%-74.7%) for their joint consumption. PAR to combined alcohol and tobacco consumption was 74% (66.5%-79.9%) in men and 45.4% (32.7%-55.6%) in women. Among suspected risk factors, body mass index 2 years before the interview <25 kg.m(-2), never tea drinking and family history of head and neck cancer explained 35.3% (25.7%-43.6%), 30.3% (14.4%-43.3%) and 5.8% (0.6%-10.8%) of cancer burden, respectively. About 93% (88.3%-95.6%) of oral cavity cancers were explained by all risk factors, 94.3% (88.4%-97.2%) in men and only 74.1% (47.0%-87.3%) in women.
conclusionOur study emphasizes the role of combined tobacco and alcohol consumption in the oral cavity cancer burden in France and gives an indication of the proportion of cases attributable to other risk factors. Most of oral cavity cancers are attributable to concurrent smoking and drinking and would be potentially preventable through smoking or drinking cessation. If the majority of cases are explained by recognized or suspected risk factors in men, a substantial number of cancers in women are probably due to still unexplored factors that remain to be clarified by future studies.
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