ArticleBrain, behavior, and immunity2016
Candesartan ameliorates impaired fear extinction induced by innate immune activation.
Article in Brain, behavior, and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Inflammatory markers in the emergency department and PTSD symptoms in the AURORA Study: A longitudinal cohort study.Psychological medicine · 2026Article
- Post-traumatic stress disorder and cardiometabolic dysfunction: Molecular mechanisms and therapeutic targets.iScience · 2026Review
- Association between steatotic liver disease and post-traumatic stress symptoms in the Fukushima health management survey.Scientific reports · 2026Article
- Sex-dependent effects of angiotensin II type 1 receptor blocker on molecular and behavioral changes induced by single prolonged stress.Behavioural brain research · 2023Article
- Antihypertensive Medications and PTSD Incidence in a Trauma Cohort.The Journal of clinical psychiatry · 2023Article
- Purinergic P2X7 receptor-mediated inflammation precedes PTSD-related behaviors in rats.Brain, behavior, and immunity · 2023Article
- The influence of sleep on fear extinction in trauma-related disorders.Neurobiology of stress · 2023Article
- The role of the immune system in posttraumatic stress disorder.Translational psychiatry · 2022Review
- Inflammation-driven brain and gut barrier dysfunction in stress and mood disorders.The European journal of neuroscience · 2022Review
- Neuroinflammation in Post-Traumatic Stress Disorder.Biomedicines · 2022Review
- Sex-dependent effects of microglial reduction on impaired fear extinction induced by single prolonged stress.Frontiers in behavioral neuroscience · 2022Article
- Rapidly GrowingInternational journal of molecular sciences · 2021Review
- Losartan improved hippocampal long-term potentiation impairment induced by repeated LPS injection in rats.Physiological reports · 2021Article
- Article
- Dysregulation of inflammation, neurobiology, and cognitive function in PTSD: an integrative review.Cognitive, affective & behavioral neuroscience · 2020Review
- Age-Related Changes in Ang II Receptor Localization and Expression in the Developing Auditory Pathway.Neurochemical research · 2019Article
- Rodent models of impaired fear extinction.Psychopharmacology · 2019Review
- Immune signaling mechanisms of PTSD risk and symptom development: insights from animal models.Current opinion in behavioral sciences · 2017Article
- Minocycline attenuates interferon-α-induced impairments in rat fear extinction.Journal of neuroinflammation · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Patients with post-traumatic stress disorder (PTSD) tend to show signs of a relatively increased inflammatory state suggesting that activation of the immune system may contribute to the development of PTSD. In the present study, we tested whether activation of the innate immune system can disrupt acquisition or recall of auditory fear extinction using an animal model of PTSD. Male adolescent rats received auditory fear conditioning in context A. The next day, an intraperitoneal injection of lipopolysaccharide (LPS; 100 μg/kg) prior to auditory fear extinction in context B impaired acquisition and recall of extinction. LPS (100 μg/kg) given after extinction training did not impair extinction recall suggesting that LPS did not affect consolidation of extinction. In contrast to cued fear extinction, contextual fear extinction was not affected by prior injection of LPS (100 μg/kg). Although LPS also reduced locomotion, we could dissociate the effects of LPS on extinction and locomotion by using a lower dose of LPS (50 μg/kg) which impaired locomotion without affecting extinction. In addition, 15 h after an injection of 250 μg/kg LPS in adult rats, extinction learning and recall were impaired without affecting locomotion. A sub-chronic treatment with candesartan, an angiotensin II type 1 receptor blocker, prevented the LPS-induced impairment of extinction in adult rats. Our results demonstrate that activation of the innate immune system can disrupt auditory fear extinction in adolescent and adult animals. These findings also provide direction for clinical studies of novel treatments that modulate the innate immune system for stress-related disorders like PTSD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.