ArticleBiological research2015
A study on β-defensin-2 and histatin-5 as a diagnostic marker of early childhood caries progression.
Article in Biological research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Pooled it
- Efficacy of biotene and xerostom on salivary function, biomarkers, and caries risk in radiation-induced xerostomia: A randomized controlled trial.Journal of conservative dentistry and endodontics · 2026Article
- Article
- Salivary innate immune peptides are associated with dental caries experience in young adults.Clinical oral investigations · 2026Article
- A Comparative Analysis of Differences in Salivary hBD-2 Levels and Their Correlation with Dental Caries and Unstimulated Saliva pH in Children with Primary and Permanent Dentition.Diagnostics (Basel, Switzerland) · 2026Article
- Natural and induced immune responses in oral cavity and saliva.BMC immunology · 2025Review
- Exploring the interplay of vitamin D, salivary antimicrobial peptides, and cytokines in oral immunity and disease prevention: an insight for implications in oral health policy.Frontiers in oral health · 2025Article
- Polymicrobial detection and salivary metabolomics of children with early childhood caries.PeerJ · 2025Article
- Salivary Antimicrobial Peptide Histatin-5 Does Not Display Zn(II)-Dependent or -Independent Activity against Streptococci.ACS infectious diseases · 2023Article
- Review
- Review
- Untargeted metabolomics of saliva in caries-active and caries-free children in the mixed dentition.Frontiers in cellular and infection microbiology · 2023Article
- Comparison of oral cavity protein abundance among caries-free and caries-affected individuals-a systematic review and meta-analysis.Frontiers in oral health · 2023Review
- Role of Salivary Biomarkers in Diagnosis and Detection of Dental Caries: A Systematic Review.Diagnostics (Basel, Switzerland) · 2022Review
- Tuft Cells Are Present in Submandibular Glands Across Species.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022Article
- Oral innate immunity in patients with type 2 diabetes mellitus in a tertiary hospital in Ibadan Nigeria: a cross-sectional study.The Pan African medical journal · 2022Article
- A Novel Role for Histatin 5 in Combination with Zinc to Promote Commensalism inPathogens (Basel, Switzerland) · 2021Article
- Analysis of salivary proteomic biomarkers for the surveillance of changes in high-risk status of early childhood caries.BMC oral health · 2021Article
- Associations of early childhood caries with salivary beta defensin-3 and childhood anemia: a case-control study.BMC oral health · 2021Article
- A Mini Review: The Potential Biomarkers for Non-invasive Diagnosis of Pulpal Inflammation.Frontiers in dental medicine · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, a continuous growth of interest has been observed in antimicrobial peptides (AMPs) in the light of an alarming increase in resistance of bacteria and fungi against antibiotics. AMPs are used as biomarkers in diagnosis and monitoring of oral cavity pathologies. Therefore, the determination of specific protein profiles in children diagnosed with early childhood caries (ECC) might be a basis for effective screening tests and specialized examinations which may enable progression of disease.
methodsThe objective of the studies was to determine the role of histatin-5 and β-defensing-2 as a diagnostic marker of early childhood caries progression. In this work, results of concentration determination of two salivary proteins (histatin-5 and β-defensin-2) were presented. In addition, bacterial profiles from dental plaque in various stages of ECC and control were marked. The assessment of alteration in the concentration of these two proteins in a study group of children with various stages of ECC and a control group consisting of children with no symptoms was performed by enzyme-linked immunosorbent assays.
resultsThe statistical analysis showed a significant increase in the concentration of histatin-5 and β-defensin-2 in the study group compared to the control group and correlated with the progression of the disease.
conclusionsThe confirmation of concentration changes in these proteins during the progression of dental caries may discover valuable disease progression biomarkers.
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