Evidence map›Paper›PMID 26520005›Full record

ReviewTrends in parasitology2016

Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick-Host Interactions.

Jindřich Chmelař, Jan Kotál, Shahid Karim, Petr Kopacek, Ivo M B Francischetti, Joao H F Pedra, Michail Kotsyfakis

Abstract readReview
In one paragraph

Review in Trends in parasitology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Critical roles ofInfection and immunity · 2024
    Article
  7. Article
  8. Review
  9. Bioinformatic Analysis ofInternational journal of molecular sciences · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Serpins in Tick Physiology and Tick-Host Interaction.Frontiers in cellular and infection microbiology · 2022
    Review
  15. The environment, the tick, and the pathogen - It is an ensemble.Frontiers in cellular and infection microbiology · 2022
    Review
  16. Article
  17. Review
  18. Monitoring Risk: Tick andPathogens (Basel, Switzerland) · 2021
    Article
  19. Article
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jindřich ChmelařFaculty of Science, University of South Bohemia in České Budějovice, Budweis, Czech Republic; Department of Clinical Pathobiochemistry, Technische Universität Dresden, Dresden, Germany.
Jan KotálFaculty of Science, University of South Bohemia in České Budějovice, Budweis, Czech Republic; Institute of Parasitology, Biology Center, Czech Academy of Sciences, Budweis, Czech Republic.
Shahid KarimDepartment of Biological Sciences, The University of Southern Mississippi, Hattiesburg, MS, USA.
Petr KopacekInstitute of Parasitology, Biology Center, Czech Academy of Sciences, Budweis, Czech Republic.
Ivo M B FrancischettiSection of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Joao H F PedraDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
Michail KotsyfakisInstitute of Parasitology, Biology Center, Czech Academy of Sciences, Budweis, Czech Republic. Electronic address: mich_kotsyfakis@yahoo.com.

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
Rickettsial Immunity During Tick TransmissionR01AI093653 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2011 to 2015
$1.8M
Intramural NIH HHSNIAID NIH HHS R01 AI093653NIGMS NIH HHS P20 GM103476
6 · The paper itself

Abstract

Tick saliva facilitates tick feeding and infection of the host. Gene expression analysis of tick salivary glands and other tissues involved in host-pathogen interactions has revealed a wide range of bioactive tick proteins. Transcriptomic analysis has been a milestone in the field and has recently been enhanced by next-generation sequencing (NGS). Furthermore, the application of quantitative proteomics to ticks with unknown genomes has provided deeper insights into the molecular mechanisms underlying tick hematophagy, pathogen transmission, and tick-host-pathogen interactions. We review current knowledge on the transcriptomics and proteomics of tick tissues from a systems-biology perspective and discuss future challenges in the field.

Indexed as

ProteomeSystems BiologyTranscriptomeAnimalsHost-Parasite InteractionsHumansTicksProteomenext-generation sequencingsialomessystems biologytick-borne pathogens

Identifiers

PMID26520005
PMCPMC4767689

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.