Evidence map›Paper›PMID 26519887›Full record

ArticleArchives of biochemistry and biophysics2015

The chemical biology of hydropersulfides (RSSH): Chemical stability, reactivity and redox roles.

Simran S Saund, Victor Sosa, Stephanie Henriquez, Q Nhu N Nguyen, Christopher L Bianco, Shuhei Soeda, Robert Millikin, Corey White, Henry Le, Katsuhiko Ono and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of biochemistry and biophysics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
  2. A Dinuclear Iron(II) Persulfide Complex Reacts with OJournal of the American Chemical Society · 2026
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  13. Review
  14. Review
  15. Methods in sulfide and persulfide research.Nitric oxide : biology and chemistry · 2021
    Article
  16. Review
  17. Article
  18. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Simran S SaundDepartment of Chemistry, Sonoma State University, Rohnert Park, CA, 94928, USA.
Victor SosaDepartment of Chemistry, Sonoma State University, Rohnert Park, CA, 94928, USA.
Stephanie HenriquezDepartment of Biology, Sonoma State University, Rohnert Park, CA, 94928, USA.
Q Nhu N NguyenDepartment of Chemistry, University of California, Davis, One Shield Ave., Davis, CA, 95616, USA.
Christopher L BiancoDepartment of Chemistry, Sonoma State University, Rohnert Park, CA, 94928, USA.
Shuhei SoedaDepartment of Chemistry, Sonoma State University, Rohnert Park, CA, 94928, USA.
Robert MillikinDepartment of Chemistry, Sonoma State University, Rohnert Park, CA, 94928, USA.
Corey WhiteDepartment of Chemistry, Sonoma State University, Rohnert Park, CA, 94928, USA.
Henry LeDepartment of Chemistry, Sonoma State University, Rohnert Park, CA, 94928, USA.
Katsuhiko OnoDepartment of Chemistry, Sonoma State University, Rohnert Park, CA, 94928, USA.
Dean J TantilloDepartment of Chemistry, University of California, Davis, One Shield Ave., Davis, CA, 95616, USA.
Yoshito KumagaiEnvironmental Biology Section, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Takaaki AkaikeDepartment of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan.
Joseph LinDepartment of Biology, Sonoma State University, Rohnert Park, CA, 94928, USA. Electronic address: linj@sonoma.edu.
Jon M FukutoDepartment of Chemistry, Sonoma State University, Rohnert Park, CA, 94928, USA. Electronic address: fukuto@sonoma.edu.
Sonoma State University · USUniversity of California, Davis · USTohoku University · JPUniversity of Tsukuba · JP

Funding

Biological Chemistry and Pharmacology of Nitroxyl (HNO)R15HL106598 · NHLBI · SONOMA STATE UNIVERSITY · PI FUKUTO, JON · 2012 to 2012
$357k
NHLBI NIH HHS HL106598NHLBI NIH HHS R15 HL106598
6 · The paper itself

Abstract

Recent reports indicate the ubiquitous prevalence of hydropersulfides (RSSH) in mammalian systems. The biological utility of these and related species is currently a matter of significant speculation. The function, lifetime and fate of hydropersulfides will be assuredly based on their chemical properties and reactivity. Thus, to serve as the basis for further mechanistic studies regarding hydropersulfide biology, some of the basic chemical properties/reactivity of hydropersulfides was studied. The nucleophilicity, electrophilicity and redox properties of hydropersulfides were examined under biological conditions. These studies indicate that hydropersulfides can be nucleophilic or electrophilic, depending on the pH (i.e. the protonation state) and can act as good one- and two-electron reductants. These diverse chemical properties in a single species make hydropersulfides chemically distinct from other, well-known sulfur containing biological species, giving them unique and potentially important biological function.

Indexed as

AnimalsCyanidesCystathionine gamma-LyaseGlutathioneHumansMagnetic Resonance SpectroscopyModels, ChemicalOxidation-ReductionPeptide FragmentsRatsReceptor-Like Protein Tyrosine Phosphatases, Class 3Recombinant ProteinsSignal TransductionSulfidesCyanidesCystathionine gamma-LyaseGlutathionePeptide FragmentspersulfidesPTPRJ protein, humanReceptor-Like Protein Tyrosine Phosphatases, Class 3Recombinant ProteinsSulfidesElectrophilicityHydropersulfideNucleophilicityRedox regulationThiols

Identifiers

PMID26519887
PMCPMC4833115
OpenAlexW2195408206

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.