ArticleJournal of medical virology2016
Susceptibility of HPV16 and 18 to high level disinfectants indicated for semi-critical ultrasound probes.
Article in Journal of medical virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Society for Maternal-Fetal Medicine Special Statement: Reducing the risk of transmitting infection during ultrasound examination-Updated 2026.Pregnancy (Hoboken, N.J.) · 2026Article
- Human Papillomavirus: Update in Bridging Basic Science to Clinical and Public Health Innovations.Health science reports · 2026Article
- Comparing In Vitro Virucidal Efficacy of Commercially Available Mouthwashes Against Native High-Risk Human Papillomavirus Types 16 and 18.Microorganisms · 2025Article
- Optimizing Ultrasound Probe Disinfection for Healthcare-Associated Infection Control: A Comparative Analysis of Disinfectant Efficacy.Microorganisms · 2024Review
- Is 0.5% hydrogen peroxide effective against SARS-CoV-2?Oral diseases · 2022Article
- Inactivation of Polyomavirus SV40 as Surrogate for Human Papillomaviruses by Chemical Disinfectants.Viruses · 2021Article
- Evaluating the Virucidal Activity of Disinfectants According to European Union Standards.Viruses · 2021Review
- Streamlining Disease Risk Analysis for Wildlife Using the Shark Bay Bandicoot as a Model.EcoHealth · 2021Article
- New approaches for infective HPV detection, quantification and inactivation: Preventing accidental virus transmission in medical settings.EBioMedicine · 2021Article
- Article
- The ability of two chlorine dioxide chemistries to inactivate human papillomavirus-contaminated endocavitary ultrasound probes and nasendoscopes.Journal of medical virology · 2020Article
- Sanitizing agents for virus inactivation and disinfection.View (Beijing, China) · 2020Review
- Decontamination of Intravaginal Probes Infected by Human Papillomavirus (HPV) Using UV-C Decontamination System.Journal of clinical medicine · 2019Article
- Development of an in vivo infection model to study Mouse papillomavirus-1 (MmuPV1).Journal of virological methods · 2018Article
- Infection prevention and control in ultrasound - best practice recommendations from the European Society of Radiology Ultrasound Working Group.Insights into imaging · 2017Article
- The wide spectrum high biocidal potency of Bioxy formulation when dissolved in water at different concentrations.PloS one · 2017Article
- UVC radiation as an effective disinfectant method to inactivate human papillomaviruses.PloS one · 2017Article
- Virucidal efficacy of a sonicated hydrogen peroxide system (trophonGMS hygiene and infection control · 2017Article
- Disinfection and Sterilization in Health Care Facilities: An Overview and Current Issues.Infectious disease clinics of North America · 2016Review
- Effectiveness of a Hydrogen Peroxide Mist (Trophon) System in Inactivating Healthcare Pathogens on Surface and Endocavitary Probes.Infection control and hospital epidemiology · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultrasound probes used in endocavitary procedures have been shown to be contaminated with high-risk HPV after routine use and HPV is also known to be resistant to some high level disinfectants (HLDs). This study compared efficacy of two leading ultrasound probe HLD methods; liquid ortho-phthalaldehyde (Cidex® OPA) and an automated device using sonicated hydrogen peroxide (trophon® EPR) against HPV16 and HPV18 in a hard-surface carrier test. Native HPV16 and HPV18 virions were generated in organotypic epithelial raft cultures. Viral lysates were dried onto carriers with a 5% (v/v) protein soil. Efficacy tests were performed against the automated device at 35% and 31.5% H2 O2 and 0.55% OPA in quadruplicate with matched input, neutralization, and cytotoxicity controls. Hypochlorite was included as a positive control. Infectivity was determined by the abundance (qRT-PCR) of the spliced E1^E4 transcript in infected recipient cells. The automated HLD device showed excellent efficacy against HPV16 and HPV18 (>5 log10 reductions in infectivity) whereas OPA showed minimal efficacy (<0.6 log10 reductions). While HPV is highly resistant to OPA, sonicated hydrogen peroxide offers an effective disinfection solution for ultrasound probes. Disinfection methods that are effective against HPV should be adopted where possible.
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