ArticleJournal of photochemistry and photobiology. B, Biology2015
Photobiomodulation with 660-nm and 780-nm laser on activated J774 macrophage-like cells: Effect on M1 inflammatory markers.
Article in Journal of photochemistry and photobiology. B, Biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness of photobiomodulation therapy in improving health indicators in obese patients: a systematic review and meta-analysis of RCTs.BMC complementary medicine and therapies · 2025Pooled it
- Review of light parameters and photobiomodulation efficacy: dive into complexity.Journal of biomedical optics · 2018Pooled it
- Effects of photobiomodulation, alone or combined with dexamethasone, on cellular metabolic activity and inflammatory markers in LPS/IFN-γ-stimulated J774 macrophages.Lasers in medical science · 2026Article
- Effects of photobiomodulation on the differentiation, viability, and migration of C2C12 myoblasts exposed to different concentrations of dexamethasone.Scientific reports · 2026Article
- Nanoparticles-based phototherapy systems: molecular mechanisms and clinical applications.Signal transduction and targeted therapy · 2026Review
- Enhancing Proliferation and Pluripotency in Human Dental Pulp Stem Cells through 980-nm Laser Irradiation: Implications for Regenerative Dentistry.Journal of lasers in medical sciences · 2026Article
- Modulating macrophage polarization by photobiomodulation.Lasers in medical science · 2025Review
- Photobiomodulation Meets Mechanotransduction: Immune-Stromal Crosstalk in Orthodontic Remodeling.Biomedicines · 2025Review
- Evaluation of laser-photobiomodulation different irradiation parameters on macrophages (RAW 264.7) inflammatory mediators' production.Lasers in medical science · 2025Article
- Immunomodulatory effects of photobiomodulation: a comprehensive review.Lasers in medical science · 2025Review
- Effects of low-level laser irradiation on osteoclastogenesis in prostaglandin ELasers in medical science · 2025Article
- In Vitro Effects of Low-Level Laser Therapy on the Viability and Secretory Activity of Resting Macrophages.Biomedicines · 2025Article
- Photobiomodulation of gut microbiota with low-level laser therapy: a light for treating neuroinflammation.Lasers in medical science · 2025Review
- Reprogramming Macrophage Phenotypes With Photobiomodulation for Improved Inflammation Control in ENT Organ Tissues.Clinical and experimental otorhinolaryngology · 2025Article
- The Use of a Proprietary Near-Infrared Laser to Enhance Wound Healing: A Preliminary Preclinical and Clinical Study.Aesthetic surgery journal. Open forum · 2025Article
- Targeted spleen modulation: a novel strategy for next-generation disease immunotherapy.Theranostics · 2025Review
- Targeting Wnt/β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds.Cell communication and signaling : CCS · 2024Review
- Photobiomodulation effects on synovial morphology, iNOS gene, and protein expression in a model of acute inflammation.Acta cirurgica brasileira · 2024Article
- Photobiomodulation Controls Keratinocytes Inflammatory Response through Nrf2 and Reduces Langerhans Cells Activation.Antioxidants (Basel, Switzerland) · 2023Article
- Photobiomodulation activates undifferentiated macrophages and promotes M1/M2 macrophage polarization via PI3K/AKT/mTOR signaling pathway.Lasers in medical science · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
M1 profile macrophages exert a major influence on initial tissue repair process. Few days after the occurrence of injury, macrophages in the injured region exhibit a M2 profile, attenuate the effects of the M1 population, and stimulate the reconstruction of the damaged tissue. The different effects of macrophages in the healing process suggest that these cells could be the target of therapeutic interventions. Photobiomodulation has been used to accelerate tissue repair, but little is known regarding its effect on macrophages. In the present study, J774 macrophages were activated to simulate the M1 profile and irradiated with two different sets of laser parameters (780 nm, 70 mW, 2.6J/cm(2), 1.5s and 660 nm, 15 mW, 7.5 J/cm(2), 20s). IL-6, TNF-α, iNOS and COX-2 gene and protein expression were analyzed by RT-qPCR and ELISA. Both lasers were able to reduce TNF-α and iNOS expression, and TNF-α and COX-2 production, although the parameters used for 780 nm laser provided an additional decrease. 660 nm laser parameters resulted in an up-regulation of IL-6 expression and production. These findings imply a distinct, time-dependent modulation by the two different sets of laser parameters, suggesting that the best modulation may involve more than one combination of parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.