Evidence map›Paper›PMID 26519527›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2015

Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women.

Morgane Griesbeck, Susanne Ziegler, Sophie Laffont, Nikaïa Smith, Lise Chauveau, Phillip Tomezsko, Armon Sharei, Georgio Kourjian, Filippos Porichis, Meghan Hart and 14 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 4 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 4 syntheses or guidelines pooled it, 242 citations in OpenAlex.

  1. Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022
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  6. Article
  7. Innate immunity: current understandings and future perspectives.Signal transduction and targeted therapy · 2026
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  9. The HIV Reservoir and Immune Landscape Across the Life Course of Women: Implications for Cure Strategies.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 7 institutions in 4 countries.

Morgane GriesbeckRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; Centre d'Immunonologie et des Maladies Infectieuses-Paris, Université Pierre et Marie Curie/INSERM U1135, Hôpital Pitié Salpêtrière, Paris 75013, France;
Susanne ZieglerHeinrich Pette Institute-Leibniz Institute for Experimental Virology, Hamburg 20246, Germany;
Sophie LaffontINSERM U1043, Toulouse F-31300, France; CNRS, U5282, Toulouse F-31300, France; Université de Toulouse, Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse F-31300, France;
Nikaïa SmithChemistry and Biology, Nucleotides and Immunology for Therapy, CNRS UMR-8601, Université Paris Descartes, Paris 75270, France;
Lise ChauveauInstitut Pasteur, Unité de recherche associée CNRS 3015, Unite Virus et Immunité, Paris 75015, France;
Phillip TomezskoRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139;ORCID http://orcid.org/0000-0003-1864-4130
Armon ShareiThe David H. Koch Institute for Integrative Cancer Research, Cambridge, MA 02139;
Georgio KourjianRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139;
Filippos PorichisRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139;ORCID http://orcid.org/0000-0002-6345-9316
Meghan HartRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139;
Christine D PalmerRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139;
Michael SirignanoRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139;
Claudia BeiselHeinrich Pette Institute-Leibniz Institute for Experimental Virology, Hamburg 20246, Germany; Medical Department, University Hospital Hamburg-Eppendorf, Hamburg 20246, Germany;
Heike HildebrandtHeinrich Pette Institute-Leibniz Institute for Experimental Virology, Hamburg 20246, Germany;
Claire CénacINSERM U1043, Toulouse F-31300, France; CNRS, U5282, Toulouse F-31300, France; Université de Toulouse, Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse F-31300, France;ORCID http://orcid.org/0000-0001-6641-7851
Alexandra-Chloé VillaniBroad Institute of MIT and Harvard, Cambridge, MA 02139; and.
Thomas J DiefenbachRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139;ORCID http://orcid.org/0000-0002-2798-5909
Sylvie Le GallRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139;
Olivier SchwartzInstitut Pasteur, Unité de recherche associée CNRS 3015, Unite Virus et Immunité, Paris 75015, France;
Jean-Philippe HerbeuvalChemistry and Biology, Nucleotides and Immunology for Therapy, CNRS UMR-8601, Université Paris Descartes, Paris 75270, France;ORCID http://orcid.org/0000-0001-8114-8012
Brigitte AutranCentre d'Immunonologie et des Maladies Infectieuses-Paris, Université Pierre et Marie Curie/INSERM U1135, Hôpital Pitié Salpêtrière, Paris 75013, France;
Jean-Charles GuéryINSERM U1043, Toulouse F-31300, France; CNRS, U5282, Toulouse F-31300, France; Université de Toulouse, Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse F-31300, France;ORCID http://orcid.org/0000-0003-4499-3270
J Judy ChangRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; Department of Infectious Diseases, Monash University, Melbourne, Victoria 3800, Australia.
Marcus AltfeldRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; Heinrich Pette Institute-Leibniz Institute for Experimental Virology, Hamburg 20246, Germany; marcus.altfeld@hpi.uni-hamburg.de.
Ragon Institute of MGH, MIT and Harvard · USCentre National de la Recherche Scientifique · FRLeibniz Institute of Virology (LIV) · DEDélégation Paris 5 · FRInserm · FRAllen Institute · USBroad Institute · US

Funding

Visualizing Effects of Costimulation on Antiviral ImmunityP01AI078897 · NIAID · HARVARD MEDICAL SCHOOL · PI VON ANDRIAN, ULRICH H · 2008 to 2012
$12.1M
TLR-mediated gender differences in HIV-1 pathogenesisR01AI078784 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ALTFELD, MARCUS · 2010 to 2013
$1.7M
NIAID NIH HHS P01 AI078897NIAID NIH HHS R01 AI078784
6 · The paper itself

Abstract

Increased IFN-α production contributes to the pathogenesis of infectious and autoimmune diseases. Plasmacytoid dendritic cells (pDCs) from females produce more IFN-α upon TLR7 stimulation than pDCs from males, yet the mechanisms underlying this difference remain unclear. In this article, we show that basal levels of IFN regulatory factor (IRF) 5 in pDCs were significantly higher in females compared with males and positively correlated with the percentage of IFN-α-secreting pDCs. Delivery of recombinant IRF5 protein into human primary pDCs increased TLR7-mediated IFN-α secretion. In mice, genetic ablation of the estrogen receptor 1 (Esr1) gene in the hematopoietic compartment or DC lineage reduced Irf5 mRNA expression in pDCs and IFN-α production. IRF5 mRNA levels furthermore correlated with ESR1 mRNA levels in human pDCs, consistent with IRF5 regulation at the transcriptional level by ESR1. Taken together, these data demonstrate a critical mechanism by which sex differences in basal pDC IRF5 expression lead to higher IFN-α production upon TLR7 stimulation in females and provide novel targets for the modulation of immune responses and inflammation.

Indexed as

Sex CharacteristicsAnimalsCells, CulturedDendritic CellsEstrogen Receptor alphaFemaleGene Expression RegulationHumansInterferon-alphaInterferon Regulatory FactorsMaleMiceMice, TransgenicRecombinant ProteinsRNA, MessengerSignal TransductionEstrogen Receptor alphaInterferon-alphaInterferon Regulatory FactorsIRF5 protein, humanRecombinant ProteinsRNA, MessengerTLR7 protein, humanToll-Like Receptor 7

Identifiers

PMID26519527
PMCPMC4654231
OpenAlexW2173859862

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.