ArticleApplied and environmental microbiology2016
Ex Vivo Application of Secreted Metabolites Produced by Soil-Inhabiting Bacillus spp. Efficiently Controls Foliar Diseases Caused by Alternaria spp.
Article in Applied and environmental microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Endophytic Aspergillus glaucus as a novel epothilone B producer: Antiproliferative activity and in silico analysis.Applied microbiology and biotechnology · 2026Article
- Cross-resistance inApplied and environmental microbiology · 2025Article
- Fermentation of waste water from agar processing with Bacillus subtilis by metabolomic analysis.Applied microbiology and biotechnology · 2024Article
- Endophytic fungi as a potential source of anti-cancer drug.Archives of microbiology · 2024Review
- Biocontrol of citrus fungal pathogens by lipopeptides produced byFrontiers in microbiology · 2024Article
- Distinguishing features ofFrontiers in plant science · 2023Article
- Biocontrol potential of lipopeptides produced by the novelFrontiers in microbiology · 2023Article
- In silico analysis of3 Biotech · 2022Article
- Anti-Fungal Analysis ofInternational journal of molecular sciences · 2022Article
- A Novel Rhizospheric Bacterium: Bacillus velezensis NKMV-3 as a Biocontrol Agent Against Alternaria Leaf Blight in Tomato.Applied biochemistry and biotechnology · 2022Article
- Genomic and Biocontrol Potential of the Crude Lipopeptide byFrontiers in microbiology · 2022Article
- Article
- Exploration of microbiome of medicinally important plants as biocontrol agents against Phytophthora parasitica.Archives of microbiology · 2021Article
- Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties.Organic letters · 2021Article
- Biosystematic studies of some Egyptian species of Cestrum (Solanaceae).Molecular biology reports · 2021Article
- Biosynthesis and Anti-Mycotoxigenic Activity ofMolecules (Basel, Switzerland) · 2021Article
- Bioremediation and tolerance of zinc ions usingHeliyon · 2020Article
- Exploiting the Biosynthetic Potency of Taxol from Fungal Endophytes of Conifers Plants; Genome Mining and Metabolic Manipulation.Molecules (Basel, Switzerland) · 2020Review
- Biocidal Activity of Metal Nanoparticles Synthesized byJournal of microbiology and biotechnology · 2020Article
- Modes of Action of Microbial Biocontrol in the Phyllosphere.Frontiers in microbiology · 2020Review
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Authors and funding
7 authors.
Funding
Abstract
Bacterial biological control agents (BCAs) are largely used as live products to control plant pathogens. However, due to variable environmental and ecological factors, live BCAs usually fail to produce desirable results against foliar pathogens. In this study, we investigated the potential of cell-free culture filtrates of 12 different bacterial BCAs isolated from flower beds for controlling foliar diseases caused by Alternaria spp. In vitro studies showed that culture filtrates from two isolates belonging to Bacillus subtilis and Bacillus amyloliquefaciens displayed strong efficacy and potencies against Alternaria spp. The antimicrobial activity of the culture filtrate of these two biological control agents was effective over a wider range of pH (3.0 to 9.0) and was not affected by autoclaving or proteolysis. Comparative liquid chromatography-mass spectrometry (LC-MS) analyses showed that a complex mixture of cyclic lipopeptides, primarily of the fengycin A and fengycin B families, was significantly higher in these two BCAs than inactive Bacillus spp. Interaction studies with mixtures of culture filtrates of these two species revealed additive activity, suggesting that they produce similar products, which was confirmed by LC-tandem MS analyses. In in planta pre- and postinoculation trials, foliar application of culture filtrates of B. subtilis reduced lesion sizes and lesion frequencies caused by Alternaria alternata by 68 to 81%. Taken together, our studies suggest that instead of live bacteria, culture filtrates of B. subtilis and B. amyloliquefaciens can be applied either individually or in combination for controlling foliar diseases caused by Alternaria species.
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