ArticleThe Journal of comparative neurology2016
Intracortical connections are altered after long-standing deprivation of dorsal column inputs in the hand region of area 3b in squirrel monkeys.
Article in The Journal of comparative neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Tactile learning transfer from the hand to the face but not to the forearm implies a special hand-face relationship.Scientific reports · 2018Trial
- Myeloarchitecture, intra- and interhemispheric and thalamocortical connections of area 3b representing the teeth and tongue in galagos.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Characterizing Evoked Movement Patterns and Connectivity in Sensorimotor Cortex After Sensory Loss in Squirrel Monkeys.The Journal of comparative neurology · 2025Article
- Cortical reorganization following dorsal spinal injuries in newborn monkeys reveals a critical period in the development of the somatosensory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sources of Rapid and Delayed New Lower Jaw Input in the Forepaw Barrel Subfield (FBS) in Rat Primary Somatosensory Cortex (SI) Following Forelimb Deafferentation.The Journal of comparative neurology · 2024Article
- Against cortical reorganisation.eLife · 2023Article
- Regressive changes in sizes of somatosensory cuneate nucleus after sensory loss in primates.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Longitudinal fMRI measures of cortical reactivation and hand use with and without training after sensory loss in primates.NeuroImage · 2021Article
- Corticocuneate projections are altered after spinal cord dorsal column lesions in New World monkeys.The Journal of comparative neurology · 2021Article
- Sensory Circuit Remodeling and Movement Recovery After Spinal Cord Injury.Frontiers in neuroscience · 2021Review
- Remapping in Cerebral and Cerebellar Cortices Is Not Restricted by Somatotopy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Reorganization of Higher-Order Somatosensory Cortex After Sensory Loss from Hand in Squirrel Monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Article
- Cortical Reorganization of Sensorimotor Systems and the Role of Intracortical Circuits After Spinal Cord Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Development of an optogenetic toolkit for neural circuit dissection in squirrel monkeys.Scientific reports · 2018Article
- Second-order spinal cord pathway contributes to cortical responses after long recoveries from dorsal column injury in squirrel monkeys.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Improving the Application of High Molecular Weight Biotinylated Dextran Amine for Thalamocortical Projection Tracing in the Rat.Journal of visualized experiments : JoVE · 2018Article
- Body Topography Parcellates Human Sensory and Motor Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Stability of Sensory Topographies in Adult Cortex.Trends in cognitive sciences · 2017Review
- Spatiotemporal trajectories of reactivation of somatosensory cortex by direct and secondary pathways after dorsal column lesions in squirrel monkeys.NeuroImage · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A complete unilateral lesion of the dorsal column somatosensory pathway in the upper cervical spinal cord deactivates neurons in the hand region in contralateral somatosensory cortex (areas 3b and 1). Over weeks to months of recovery, parts of the hand region become reactivated by touch on the hand or face. To determine whether changes in cortical connections potentially contribute to this reactivation, we injected tracers into electrophysiologically identified locations in cortex of area 3b representing the reactivated hand and normally activated face in adult squirrel monkeys. Our results indicated that even when only partially reactivated, most of the expected connections of area 3b remained intact. These intact connections include the majority of intrinsic connections within area 3b; feedback connections from area 1, secondary somatosensory cortex (S2), parietal ventral area (PV), and other cortical areas; and thalamic inputs from the ventroposterior lateral nucleus (VPL). In addition, tracer injections in the reactivated hand region of area 3b labeled more neurons in the face and shoulder regions of area 3b than in normal monkeys, and injections in the face region of area 3b labeled more neurons in the hand region. Unexpectedly, the intrinsic connections within area 3b hand cortex were more widespread after incomplete dorsal column lesions (DCLs) than after a complete DCL. Although these additional connections were limited, these changes in connections may contribute to the reactivation process after injuries. J. Comp. Neurol. 524:1494-1526, 2016. © 2015 Wiley Periodicals, Inc.
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