ReviewCNS drugs2015
Impact of Antidepressant Drugs on Sexual Function and Satisfaction.
Review in CNS drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- Lost in translation: toward clinically effective translational research.Translational psychiatry · 2025Review
- Dyspareunia and pelvic pain in women with chronic migraine: A retrospective, observational analysis.Headache · 2025Observational
- Antidepressant-associated sexual dysfunction in outpatients.BMC psychiatry · 2025Article
- Neurological adverse events associated with antidepressants: a comprehensive 22-year analysis of the FDA adverse event reporting system.Frontiers in pharmacology · 2025Article
- Turkish Version of the Psychotropic Related Sexual Dysfunction Questionnaire (PRSEXDQ-T): Validity and Reliability in Patients Using Selective Serotonin Reuptake Inhibitor.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2025Article
- Influence ofCanadian journal of psychiatry. Revue canadienne de psychiatrie · 2024Article
- Article
- The Impact ofClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- Behavioral, Neural, and Molecular Mechanisms of Conditioned Mate Preference: The Role of Opioids and First Experiences of Sexual Reward.International journal of molecular sciences · 2022Review
- Enjoyment of Sexuality and Longevity in Late Midlife and Older Adults: The Longitudinal Ageing Study Amsterdam.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2022Article
- Effectiveness of Vortioxetine in Patients with Major Depressive Disorder in Real-World Clinical Practice: French Cohort Results from the Global RELIEVE Study.Neuropsychiatric disease and treatment · 2022Article
- Effectiveness of Vortioxetine in Patients with Major Depressive Disorder in Real-World Clinical Practice in Italy: Results from the RELIEVE Study.Neuropsychiatric disease and treatment · 2022Article
- Effectiveness of Vortioxetine in Patients With Major Depressive Disorder in Real-World Clinical Practice: Results of the RELIEVE Study.Frontiers in psychiatry · 2022Article
- What is the "weight" of body mass index on sexual functioning in women? A mediation model.Eating and weight disorders : EWD · 2021Article
- Acute caffeine reverses the disruptive effects of chronic fluoxetine on the sexual behavior of female and male rats.Psychopharmacology · 2021Article
- Management Strategies for Antidepressant-Related Sexual Dysfunction: A Clinical Approach.Journal of clinical medicine · 2019Review
- Frequency of Sexual Dysfunction in Patients Treated with Desvenlafaxine: A Prospective Naturalistic Study.Journal of clinical medicine · 2019Article
- Assessment and management of sexual dysfunction in the context of depression.Therapeutic advances in psychopharmacology · 2018Review
- Pharmacotherapy in Generalized Anxiety Disorder: Novel Experimental Medicine Models and Emerging Drug Targets.CNS drugs · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pleasurable sexual activity is important in many human relationships and can provide a sense of physical, emotional and social well-being. Depressive symptoms and depressive illness are associated with impairments in sexual function and sexual dissatisfaction in untreated and treated patients. Most currently available antidepressant drugs are associated with development or worsening of sexual dysfunction in a substantial proportion of patients. Sexual difficulties during antidepressant treatment often resolve as depression lifts, but can persist over long periods, reducing self-esteem and affecting mood and relationships adversely. Sexual difficulties during antidepressant treatment typically have many possible causes but the incidence and nature of dysfunction varies between drugs. Many interventions can be considered when managing sexual dysfunction associated with antidepressants but no approach is 'ideal'. Because treatment-emergent sexual difficulties are less frequent with certain drugs, presumably related to differences in pharmacological properties, and since current interventions are suboptimal, a lower incidence of sexual dysfunction is a relevant tolerability target when developing novel antidepressants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.