ArticleBMC genetics2015
A study of vertebra number in pigs confirms the association of vertnin and reveals additional QTL.
Article in BMC genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
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- Signature of Selection Analysis Reveals Candidate Genes Related to Climate Adaptation and Production Traits in Lao Native Goats.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
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- Genome-Wide Association Studies of Growth Trait Heterosis in Crossbred Meat Rabbits.Animals : an open access journal from MDPI · 2024Article
- Advancements in Genetic Marker Exploration for Livestock Vertebral Traits with a Focus on China.Animals : an open access journal from MDPI · 2024Review
- Identification of ROH Islands Conserved through Generations in Pigs Belonging to the Nero Lucano Breed.Genes · 2023Article
- Integrated Analysis of Transcriptome Expression Profiles Reveals miRNA-326-NKX3.2-Regulated Porcine Chondrocyte Differentiation.International journal of molecular sciences · 2023Article
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- Spinal fixation after laminectomy in pigs prevents postoperative spinal cord injury.Animal models and experimental medicine · 2022Article
- Genome‑wide association study and genomic prediction for growth traits in yellow-plumage chicken using genotyping-by-sequencing.Genetics, selection, evolution : GSE · 2021Article
- Single-marker and haplotype-based genome-wide association studies for the number of teats in two heavy pig breeds.Animal genetics · 2021Article
- Perosomus Elumbis in Piglets: Pathological, Radiological and Cytogenetic Findings.Animals : an open access journal from MDPI · 2021Article
- Image-guided study of swine anatomy as a tool for urologic surgery research and training.Acta cirurgica brasileira · 2021Article
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- Expression analysis and single-nucleotide polymorphisms ofArchives animal breeding · 2021Article
- A multi-breed GWAS for morphometric traits in four Beninese indigenous cattle breeds reveals loci associated with conformation, carcass and adaptive traits.BMC genomics · 2020Article
- Polymorphism ofAnimals : an open access journal from MDPI · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFormation of the vertebral column is a critical developmental stage in mammals. The strict control of this process has resulted in little variation in number of vertebrae across mammalian species and no variation within most mammalian species. The pig is quite unique as considerable variation exists in number of thoracic vertebrae as well as number of lumbar vertebrae. At least two genes have been identified that affect number of vertebrae in pigs yet considerable genetic variation still exists. Therefore, a genome-wide association (GWA) analysis was conducted to identify additional genomic regions that affect this trait.
resultsA total of 1883 animals were phenotyped for the number of ribs and thoracolumbar vertebrae as well as successfully genotyped with the Illumina Porcine SNP60 BeadChip. After data editing, 41,148 SNP markers were included in the GWA analysis. These animals were also phenotyped for kyphosis. Fifty-three 1 Mb windows each explained at least 1.0 % of the genomic variation for vertebrae counts while 16 regions were significant for kyphosis. Vertnin genotype significantly affected vertebral counts as well. The region with the largest effect for number of lumbar vertebrae and thoracolumbar vertebrae were located over the Hox B gene cluster and the largest association for thoracic vertebrae number was over the Hox A gene cluster. Genetic markers in significant regions accounted for approximately 50% of the genomic variation. Less genomic variation for kyphosis was described by QTL regions and no region was associated with kyphosis and vertebra counts.
conclusionsThe importance of the Hox gene families in vertebral development was highlighted as significant associations were detected over the A, B and C families. Further evaluation of these regions and characterization of variants within these genes will expand our knowledge on vertebral development using natural genetic variants segregating in commercial swine.
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