Evidence map›Paper›PMID 26518876›Full record

ArticleThe Journal of biological chemistry2015

Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate Receptor 2 in a Human Cholangiocarcinoma Cell Line.

Runping Liu, Xiaojiaoyang Li, Xiaoyan Qiang, Lan Luo, Phillip B Hylemon, Zhenzhou Jiang, Luyong Zhang, Huiping Zhou

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Bile acid signaling in health and disease.Molecular biomedicine · 2026
    Review
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  19. The role of bile acids in carcinogenesis.Cellular and molecular life sciences : CMLS · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Runping LiuFrom the Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu 210009, China, the Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia 23298.
Xiaojiaoyang LiFrom the Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.
Xiaoyan QiangFrom the Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu 210009, China, the Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia 23298.
Lan Luothe Jiangsu Center for Pharmacodynamics Research and Evaluation, Nanjing, Jiangsu 210009, China, and.
Phillip B Hylemonthe Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia 23298, the McGuire Veterans Affairs Medical Center, Richmond, Virginia 23298.
Zhenzhou JiangFrom the Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu 210009, China, the Jiangsu Center for Pharmacodynamics Research and Evaluation, Nanjing, Jiangsu 210009, China, and beaglejiang@cpu.edu.cn.
Luyong ZhangFrom the Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu 210009, China, the Jiangsu Center for Pharmacodynamics Research and Evaluation, Nanjing, Jiangsu 210009, China, and lyzhang@cpu.edu.cn.
Huiping Zhouthe Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia 23298, the McGuire Veterans Affairs Medical Center, Richmond, Virginia 23298 hzhou@vcu.edu.
China Pharmaceutical University · CNVirginia Commonwealth University · US

Funding

Regulation of Hepatic SphK2 by Bile Acids: Effects on Lipid MetabolismR01DK057543 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI HYLEMON, PHILLIP B, ZHOU, HUIPING ROSE · 2001 to 2015
$4.4M
NIDDK NIH HHS R01 DK057543
6 · The paper itself

Abstract

Cholangiocarcinoma (CCA) is a rare, but highly malignant primary hepatobiliary cancer with a very poor prognosis and limited treatment options. Our recent studies reported that conjugated bile acids (CBAs) promote the invasive growth of CCA via activation of sphingosine 1-phosphate receptor 2 (S1PR2). Cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) is the most abundant prostaglandin in various human malignancies including CCA. Previous studies have indicated that COX-2 was highly expressed in CCA tissues, and the survival rate of CCA patients was negatively associated with high COX-2 expression levels. It has also been reported that CBAs induce COX-2 expression, whereas free bile acids inhibit COX-2 expression in CCA mouse models. However, the underlying cellular mechanisms and connection between S1PR2 and COX-2 expression in CCA cells have still not been fully elucidated. In the current study, we examined the role of S1PR2 in conjugated bile acid (taurocholate, (TCA))-induced COX-2 expression in a human HuCCT1 CCA cell line and further identified the potential underlying cellular mechanisms. The results indicated that TCA-induced invasive growth of human CCA cells was correlated with S1PR2-medated up-regulation of COX-2 expression and PGE2 production. Inhibition of S1PR2 activation with chemical antagonist (JTE-013) or down-regulation of S1PR2 expression with gene-specific shRNA not only reduced COX-2 expression, but also inhibited TCA-induced activation of EGFR and the ERK1/2/Akt-NF-κB signaling cascade. In conclusion, S1PR2 plays a critical role in TCA-induced COX-2 expression and CCA growth and may represent a novel therapeutic target for CCA.

Indexed as

AnimalsCell Line, TumorCholangiocarcinomaCyclooxygenase 2Gene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticHumansMAP Kinase Signaling SystemMiceMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Neoplasm InvasivenessNF-kappa BProto-Oncogene Proteins c-aktPyrazolesPyridinesCyclooxygenase 2JTE 013MAPK1 protein, humanMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3NF-kappa BProto-Oncogene Proteins c-aktPTGS2 protein, humanPyrazolesPyridinesReceptors, LysosphingolipidS1PR2 protein, humanSphingosine-1-Phosphate ReceptorsTaurocholic Acidbile acidcell biologycyclooxygenase (COX)epidermal growth factor receptor (EGFR)gene regulationmetabolismsignal transductionsphingosine-1-phosphate (S1P)

Identifiers

PMID26518876
PMCPMC4692225
OpenAlexW2263583031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.