ArticleParasitology research2016
Eugenol, α-pinene and β-caryophyllene from Plectranthus barbatus essential oil as eco-friendly larvicides against malaria, dengue and Japanese encephalitis mosquito vectors.
Article in Parasitology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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70 citing papers in PubMed, 156 citations in OpenAlex.
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- Gas Chromatography-Mass Spectrometry Analysis ofInternational journal of molecular sciences · 2025Article
- Endophytes of Zingiberaceae: distribution and bioactivity of their bioactive metabolites.Archives of microbiology · 2025Review
- Chemical Composition and Larvicidal Activity AgainstMolecules (Basel, Switzerland) · 2025Article
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- Tiny Green Army: Fighting Malaria with Plants and Nanotechnology.Pharmaceutics · 2024Review
- LaMYC7, a positive regulator of linalool and caryophyllene biosynthesis, confers plant resistance toHorticulture research · 2024Article
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- Larvicidal and Adulticidal Activity of Essential Oils from Four Cuban Plants against Three Mosquito Vector Species.Plants (Basel, Switzerland) · 2023Article
- Mosquito Larvicidal Activity and Cytotoxicity of the Extracts of Aromatic Plants from Malaysia.Insects · 2023Article
- Exploring the volatile metabolites of threeSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- A New Essential Oil from the Leaves ofPlants (Basel, Switzerland) · 2023Article
- First Report on the Chemical Composition, Antioxidant Capacity, and Preliminary Toxicity toAntioxidants (Basel, Switzerland) · 2022Article
- Biodefensive Based onBiomolecules · 2022Article
- Design and Optimization of a Natural Medicine fromPolymers · 2022Article
- Potential of Essential Oil-Based Anticholinesterase Insecticides againstMolecules (Basel, Switzerland) · 2022Review
- Larvicidal and adulticidal activity of essential oils from plants of the Lamiaceae family against the West Nile virus vector,Saudi journal of biological sciences · 2022Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mosquito-borne diseases represent a deadly threat for millions of people worldwide. Eco-friendly mosquitocides are a priority. In Ayurvedic medicine, Plectranthus species have been used to treat heart disease, convulsions, spasmodic pain and painful urination. In this research, we evaluated the acute toxicity of essential oil from Plectranthus barbatus and its major constituents, against larvae of the malaria vector Anopheles subpictus, the dengue vector Aedes albopictus and the Japanese encephalitis vector Culex tritaeniorhynchus. The chemical composition of P. barbatus essential oil was analyzed by gas chromatography-mass spectroscopy. Nineteen components were identified. Major constituents were eugenol (31.12%), α-pinene (19.38%) and β-caryophyllene (18.42%). Acute toxicity against early third-instar larvae of An. subpictus, Ae. albopictus and Cx. tritaeniorhynchus was investigated. The essential oil had a significant toxic effect against larvae of An. subpictus, Ae. albopictus and Cx. tritaeniorhynchus, with 50% lethal concentration (LC50) values of 84.20, 87.25 and 94.34 μg/ml and 90% lethal concentration (LC90) values of 165.25, 170.56 and 179.58 μg/ml, respectively. Concerning major constituents, eugenol, α-pinene and β-caryophyllene appeared to be most effective against An. subpictus (LC50 = 25.45, 32.09 and 41.66 μg/ml, respectively), followed by Ae. albopictus (LC50 = 28.14, 34.09 and 44.77 μg/ml, respectively) and Cx. tritaeniorhynchus (LC50 = 30.80, 36.75 and 48.17 μg/ml, respectively). Overall, the chance to use metabolites from P. barbatus essential oil against mosquito vectors seems promising, since they are effective at low doses and could be an advantageous alternative to build newer and safer mosquito control tools.
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