Evidence map›Paper›PMID 26518581›Full record

ArticleInfection2016

Neonatal Ureaplasma urealyticum colonization increases pulmonary and cerebral morbidity despite treatment with macrolide antibiotics.

Bernhard Resch, C Gutmann, F Reiterer, J Luxner, B Urlesberger

Abstract read
PubMed Publisher
In one paragraph

Article in Infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Guideline
  2. [Advances in clinical pharmacotherapy for neonatalZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Review
  3. Article
  4. [Clinical characteristics ofZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Article
  5. Effects ofAmerican journal of translational research · 2024
    Review
  6. Article
  7. Article
  8. Maternal VaginalChildren (Basel, Switzerland) · 2021
    Article
  9. Article
  10. Article
  11. Infection Prevalence and Antibiotic Resistance Levels inThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021
    Article
  12. Review
  13. Review
  14. Bronchopulmonary dysplasia in very preterm infants: Outcome up to preschool age, in a single center of Austria.Pediatrics international : official journal of the Japan Pediatric Society · 2019
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Bernhard ReschResearch Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Graz, Austria. bernhard.resch@medunigraz.at.
C GutmannResearch Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Graz, Austria.
F ReitererDivision of Neonatology, Department of Pediatrics, Medical University of Graz, Auenbruggerplatz 34/2, 8036, Graz, Austria.
J LuxnerInstitute for Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.
B UrlesbergerDivision of Neonatology, Department of Pediatrics, Medical University of Graz, Auenbruggerplatz 34/2, 8036, Graz, Austria.
Medical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the influence of Ureaplasma urealyticum (UU) colonization on neonatal pulmonary and cerebral morbidity.

methodsSingle-center case-control study including all preterm infants with positive UU tracheal colonization between 1990 and 2012. Cases were matched with controls by birth year, gestational age, birth weight, and sex. All cases had received macrolide antibiotics for UU infection starting at the time of first positive culture results from tracheal aspirates. Main outcome parameters included presence and severity of hyaline membrane disease (IRDS), duration of ventilation, bronchopulmonary dysplasia at 36 postmenstrual age and neurological morbidities (seizures, intra-/periventricular hemorrhages-I/PVH, periventricular leukomalacia-PVL).

resultsOf 74 cases identified 8 died and 4 had to be excluded; thus, 62 preterm infants were compared to 62 matched controls. UU was significantly associated with IRDS (79 vs. 61 %, p = 0.015), BPD (24 vs. 6 %, p = 0.003), seizures (23 vs. 5 %, p = 0.002) and I/PVH (45 vs. 24 %, p = 0.028). Cases had longer duration of mechanical ventilation and total duration of invasive and non-invasive ventilation (median 11 vs. 6 days p = 0.006 and 25 vs. 16.5 days p = 0.019, respectively).

conclusionUU was found to be significantly associated with pulmonary short- and long-term morbidity and mild cerebral impairment despite treatment with macrolide antibiotics.

Indexed as

Ureaplasma urealyticumAnti-Bacterial AgentsBronchopulmonary DysplasiaCase-Control StudiesFemaleHumansInfant, NewbornInfant, Newborn, DiseasesMacrolidesMaleRespiratory Distress Syndrome, NewbornRetrospective StudiesTreatment OutcomeUreaplasma InfectionsAnti-Bacterial AgentsMacrolidesBronchopulmonary dysplasiaErythromycinIntraventricular hemorrhageRespiratory distress syndromeUreaplasma urealyticum

Identifiers

PMID26518581
OpenAlexW1959039365

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.