Evidence map›Paper›PMID 26518564›Full record

ArticleDoklady. Biochemistry and biophysics2015

Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin.

L V Yanshole, V V Yanshole, O A Snytnikova, A Zh Fursova, N G Kolosova, Yu P Tsentalovich, R Z Sagdeev

Abstract read
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In one paragraph

Article in Doklady. Biochemistry and biophysics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

L V YansholeInternational Tomography Center of the Siberian Branch of Russian Academy of the Sciences, Novosibirsk, Russia. yura@tomo.nsc.ru.
V V YansholeInternational Tomography Center of the Siberian Branch of Russian Academy of the Sciences, Novosibirsk, Russia.
O A SnytnikovaInternational Tomography Center of the Siberian Branch of Russian Academy of the Sciences, Novosibirsk, Russia.
A Zh FursovaNovosibirsk State Regional Clinical Hospital, Novosibirsk, Russia.
N G KolosovaInstitute of Cytology and Genetics of the Siberian Branch of Russian Academy of the Sciences, Novosibirsk, Russia.
Yu P TsentalovichInternational Tomography Center of the Siberian Branch of Russian Academy of the Sciences, Novosibirsk, Russia.
R Z SagdeevInternational Tomography Center of the Siberian Branch of Russian Academy of the Sciences, Novosibirsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of SkQ1 eye drops to slow down the cataract development is demonstrated on the senescence-accelerated OXYS rats: the SkQ1 treatment leads to the considerable improvement of the lens condition as compared to the control group. The comparison of the chaperone activities of α-crystallins isolated from the rat lenses did not reveal significant difference between SkQ1-treated and control rats. The contents of major metabolites (23 compounds) in lenses of SkQ1-treated and untreated rats are also very similar, though the concentration of reduced glutathione (GSH) in lenses of SkQ1-treated rats is 12% lower. This difference may be attributed to the reduction of the oxidative stress under action of SkQ1 eye drops, and to the decreased requirement to produce high amounts of this antioxidant.

Indexed as

Agingalpha-CrystallinsAnimalsbeta-CrystallinsCataractDisease Models, AnimalFree Radical ScavengersGlutathioneKineticsLens, CrystallineOphthalmic SolutionsOxidative StressPlastoquinoneProtein MultimerizationRats10-(6'-plastoquinonyl)decyltriphenylphosphoniumalpha-Crystallinsbeta-CrystallinsFree Radical ScavengersGlutathioneOphthalmic SolutionsPlastoquinone

Identifiers

PMID26518564

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.