Evidence map›Paper›PMID 26518561›Full record

ArticleDoklady. Biochemistry and biophysics2015

DNA methylation of genes of the main components of the telomerase complex in Danio rerio.

E V Belova, A E Kozlov, O S Shubernetskaya, M I Zvereva, O V Shpanchenko, O A Dontsova

Abstract read
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In one paragraph

Article in Doklady. Biochemistry and biophysics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

E V BelovaChemical Department, Moscow State University, Moscow, 119991, Russia.
A E KozlovChemical Department, Moscow State University, Moscow, 119991, Russia.
O S ShubernetskayaChemical Department, Moscow State University, Moscow, 119991, Russia.
M I ZverevaChemical Department, Moscow State University, Moscow, 119991, Russia.
O V ShpanchenkoChemical Department, Moscow State University, Moscow, 119991, Russia. olgash@genebee.msu.ru.
O A DontsovaChemical Department, Moscow State University, Moscow, 119991, Russia.
Lomonosov Moscow State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The methylation status of the genes of telomerase reverse transcriptase (tert) and telomerase RNA (terc) was determined in brain tissues of Danio rerio of different age. It is found that, regardless of the age of fish, the regulatory region of the tert gene was completely methylated, whereas the coding region remained unmethylated in all cases. The level of methylation of the region located downstream of the coding region of the terc gene changes with age. This region was analyzed in the samples of other tissues, and its methylation status was also nonuniform. The alteration of the methylation status in the 3'-untranslated region of the terc gene suggests the possibility of transcription of the antisense strand in this region.

Indexed as

CpG IslandsDNA MethylationAgingAnimalsBrainPolymerase Chain ReactionRNATelomeraseZebrafishRNATelomerasetelomerase RNA

Identifiers

PMID26518561
OpenAlexW1822924688

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.