Evidence map›Paper›PMID 26518547›Full record

ArticleDoklady. Biochemistry and biophysics2015

Involvement of the Arp2/3 complex and WASP proteins in the effect of glutoxim and molixan on intracellular Ca(2+) concentration in macrophages.

Z I Krutetskaya, L S Milenina, A A Naumova, S N Butov, V G Antonov, A D Nozdrachev

Abstract read
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Article in Doklady. Biochemistry and biophysics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Z I KrutetskayaSt. Petersburg State University, St. Petersburg, 199034, Russia. zk@bio.spbu.ru.
L S MileninaSt. Petersburg State University, St. Petersburg, 199034, Russia.
A A NaumovaSt. Petersburg State University, St. Petersburg, 199034, Russia.
S N ButovSt. Petersburg State University, St. Petersburg, 199034, Russia.
V G AntonovSt. Petersburg State University, St. Petersburg, 199034, Russia.
A D NozdrachevSt. Petersburg State University, St. Petersburg, 199034, Russia.
St Petersburg University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Fura-2AM fluorescent Ca(2+) probe was used to study the possibility that the Arp2/3 complex and WASP proteins are involved in the effects of glutoxim and molixan on the intracellular Ca(2+) concentration in macrophages. It has been demonstrated that preincubation of macrophages with inhibitors of the Arp2/3 complex or WASP proteins (CK-0944666 or wiskostatin, respectively) results in a significant suppression of Ca(2+)-responses induced by glutoxim or molixan. This suggests that polymerization of actin filaments is a process involved in the effect of glutoxim or molixan on intracellular Ca(2+) concentration in macrophages.

Indexed as

Actin-Related Protein 2-3 ComplexAnimalsCalciumCarbazolesCations, DivalentCells, CulturedDrug CombinationsFluorescent DyesFura-2GlutathioneIndolesInosineMacrophages, PeritonealOligopeptidesPropanolaminesRats, WistarActin-Related Protein 2-3 ComplexCalciumCarbazolesCations, DivalentCK-0944666Drug CombinationsFluorescent DyesFura-2fura-2-amGlutathioneglutoximIndolesInosineOligopeptidesPropanolamineswiskostatinWiskott-Aldrich Syndrome Protein Family

Identifiers

PMID26518547
OpenAlexW2173002763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.