ArticleArchives of disease in childhood. Fetal and neonatal edition2016
Heart rate characteristic index monitoring for bloodstream infection in an NICU: a 3-year experience.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Heart Rate Characteristics Monitoring for Late-Onset Sepsis in Preterm Infants: A Systematic Review.Neonatology · 2023Pooled it
- A multimodal vision dataset for nursing action recognition and quality assessment in NICU.Scientific data · 2026Article
- Future perspectives of heart rate and oxygenation monitoring in the neonatal intensive care unit - a narrative review.Journal of clinical monitoring and computing · 2025Review
- Establishing normative values for short-term heart rate variability indices in healthy infants in the emergency department.Annals of translational medicine · 2025Article
- Hemoglobin, Ferritin, and Lactate Dehydrogenase as Predictive Markers for Neonatal Sepsis.Journal of personalized medicine · 2024Article
- Framework for Considering Abnormal Heart Rate Characteristics and Other Signs of Sepsis in Very Low Birth Weight Infants.American journal of perinatology · 2024Article
- The Relationship Between Blood Culture, C-reactive Protein, and Neonatal Sepsis: A Cross-Sectional Study.Cureus · 2024Article
- Association Between Hypoglycemia and the Occurrence of Early Onset Sepsis in Premature Infants.Journal of the Pediatric Infectious Diseases Society · 2023Article
- Novel approaches to capturing and using continuous cardiorespiratory physiological data in hospitalized children.Pediatric research · 2023Review
- Introducing heart rate variability monitoring combined with biomarker screening into a level IV NICU: a prospective implementation study.European journal of pediatrics · 2022Article
- Using Temporal Data Mining on Patient Data for Clinical Decision Making in the Care of the Sick Newborn.EC paediatrics : open access · 2022Article
- The principles of whole-hospital predictive analytics monitoring for clinical medicine originated in the neonatal ICU.NPJ digital medicine · 2022Review
- MicroRNA as an Early Biomarker of Neonatal Sepsis.Frontiers in pediatrics · 2022Review
- Knowledge gaps in late-onset neonatal sepsis in preterm neonates: a roadmap for future research.Pediatric research · 2022Review
- Neonatal heart rate variability: a contemporary scoping review of analysis methods and clinical applications.BMJ open · 2021Article
- Stratified Management for Bacterial Infections in Late Preterm and Term Neonates: Current Strategies and Future Opportunities Toward Precision Medicine.Frontiers in pediatrics · 2021Review
- Comparison of multiple cardiac signal acquisition technologies for heart rate variability analysis.Journal of clinical monitoring and computing · 2020Article
- A narrative review of heart rate and variability in sepsis.Annals of translational medicine · 2020Review
- Cardiorespiratory Alterations in a Newborn Ovine Model of Systemic Inflammation Induced by Lipopolysaccharide Injection.Frontiers in physiology · 2020Article
- Rational Use of Antibiotics in Neonates: Still in Search of Tailored Tools.Healthcare (Basel, Switzerland) · 2019Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBloodstream infection (BSI) among neonatal intensive care unit (NICU) infants is a frequent problem associated with poor outcomes. Monitoring for abnormal heart rate characteristics (HRCs) may decrease infant mortality by alerting clinicians to sepsis before it becomes clinically apparent.
methodsHRC scores were acquired using the HRC (HeRO) monitor system from Medical Predictive Science Corporation and entered into the electronic medical record by bedside staff. We retrospectively analysed HRC scores recorded twice daily in the medical record during a 30-month period (1 January 2010 through 30 June 2012) for infants in the NICU at the Monroe Carell Jr. Children's Hospital at Vanderbilt. We identified infants that met Centers for Disease Control criteria for late-onset BSI (>3 days of life) during the study period.
resultsDuring the study period, we recorded 127 673 HRC scores from 2384 infants. We identified 46 infants with BSI. Although 8% (9701/127 673) of the HRC scores were ≥2 and 1% (1387/127 673) were ≥5, BSI (at any time) was observed in just 5% of patients with HRC scores ≥2, and 9% of patients with HRC scores ≥5. Of infants with BSI, 5/46 (11%) had at least one HRC score ≥5 and 17/46 (37%) had at least one score ≥2 recorded in the 48 h period prior to the evaluation that resulted in the first positive blood culture of the episode.
conclusionsIn our single-centre retrospective study, elevated HRC scores had limited ability to detect BSI. BSI was infrequent at any time during hospitalisation in infants with significantly elevated HRC scores.
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