ArticleBMC genomics2015
The epigenetic processes of meiosis in male mice are broadly affected by the widely used herbicide atrazine.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Meta-analysis and experimental validation identified atrazine as a toxicant in the male reproductive system.Environmental science and pollution research international · 2021Pooled it
- Niosomal l-carnitine and quercetin improve sperm quality and testicular function in atrazine-induced reproductive toxicity in rats.Scientific reports · 2026Article
- A Review on the Effects of Atrazine on Male Rat Reproductive System Cytoarchitecture, Steroidogenesis and Oxidative Pathway.Journal of molecular histology · 2026Review
- Effect of environmental contamination on male and female gametes.The Journal of reproduction and development · 2026Review
- Adolescent psychological stress impairs spermatogenesis by disrupting meiotic progression in male mice.PeerJ · 2026Article
- Prenatal nicotine exposure induces epigenetic alterations in the Notch signaling genes in the proximal colon in rats.BMC genomics · 2025Article
- Environmental Stress-Induced Alterations in Embryo Developmental Morphokinetics.Journal of xenobiotics · 2024Review
- Oocyte Development and Quality in Young and Old Mice following Exposure to Atrazine.Environmental health perspectives · 2022Article
- In utero exposure to chlordecone affects histone modifications and activates LINE-1 in cord blood.Life science alliance · 2021Article
- Epigenetic Changes Associated With Exposure to Glyphosate-Based Herbicides in Mammals.Frontiers in endocrinology · 2021Review
- Immune and Nervous Systems Interaction in Endocrine Disruptors Toxicity: The Case of Atrazine.Frontiers in toxicology · 2021Review
- Environmental Impact on Male (In)Fertility via Epigenetic Route.Journal of clinical medicine · 2020Review
- Effect of environmental contamination on female and male gametes - A lesson from bovines.Animal reproduction · 2020Review
- Atrazine induces penis abnormalities including hypospadias in mice.Journal of developmental origins of health and disease · 2020Article
- Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice†.Biology of reproduction · 2020Article
- Mechanisms of action of agrochemicals acting as endocrine disrupting chemicals.Molecular and cellular endocrinology · 2020Review
- Article
- Chronic Atrazine Exposure Beginning Prenatally Impacts Liver Function and Sperm Concentration With Multi-Generational Consequences in Mice.Frontiers in endocrinology · 2020Article
- Atrazine exposure in gestation and breastfeeding affects Calomys laucha sperm cells.Environmental science and pollution research international · 2019Article
- The effect of crocin on testicular tissue and sperm parameters of mice offspring from mothers exposed to atrazine during pregnancy and lactation periods: An experimental study.International journal of reproductive biomedicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEnvironmental factors such as pesticides can cause phenotypic changes in various organisms, including mammals. We studied the effects of the widely used herbicide atrazine (ATZ) on meiosis, a key step of gametogenesis, in male mice.
methodsGene expression pattern was analysed by Gene-Chip array. Genome-wide mapping of H3K4me3 marks distribution was done by ChIP-sequencing of testis tissue using Illumina technologies. RT-qPCR was used to validate differentially expressed genes or differential peaks.
resultsWe demonstrate that exposure to ATZ reduces testosterone levels and the number of spermatozoa in the epididymis and delays meiosis. Using Gene-Chip and ChIP-Seq analysis of H3K4me3 marks, we found that a broad range of cellular functions, including GTPase activity, mitochondrial function and steroid-hormone metabolism, are affected by ATZ. Furthermore, treated mice display enriched histone H3K4me3 marks in regions of strong recombination (double-strand break sites), within very large genes and reduced marks in the pseudoautosomal region of X chromosome.
conclusionsOur data demonstrate that atrazine exposure interferes with normal meiosis, which affects spermatozoa production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.