ArticleEndocrine2016
A meta-analysis-derived proposal for a clinical, ultrasonographic, and cytological scoring system to evaluate thyroid nodules: the "CUT" score.
Article in Endocrine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative analysis of diagnostic performance, feasibility and cost of different test-methods for thyroid nodules with indeterminate cytology.Oncotarget · 2017Pooled it
- Article
- Comprehensive evaluation of TIR 3B thyroid nodules: Clinical, Ultrasonographical and Cytological features for prediction of malignancy.Endocrine · 2026Article
- Utility of the Clinical and Radiological Features in the Management of Bethesda 3 and 4 Thyroid Nodules.Indian journal of surgical oncology · 2025Article
- External Validation of a Predictive Model for Thyroid Cancer Risk with Decision Curve Analysis.Diagnostics (Basel, Switzerland) · 2025Article
- Ultrasound Parameters Can Accurately Predict the Risk of Malignancy in Patients with "Indeterminate TIR3b" Cytology Nodules: A Prospective Study.International journal of molecular sciences · 2023Article
- Editorial: Subclassification of AUS/FLUS category for thyroid nodules: trials and evidence-based clinical management.Frontiers in endocrinology · 2023Article
- Validating the 'CUT score' risk stratification tool for indeterminate thyroid nodules using the Bethesda system for reporting thyroid cytopathology.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Diagnostic performance of Midkine ratios in fine-needle aspirates for evaluation of Cytologically indeterminate thyroid nodules.Diagnostic pathology · 2021Article
- Comparison of Korean vs. American Thyroid Imaging Reporting and Data System in Malignancy Risk Assessment of Indeterminate Thyroid Nodules.Endocrinology and metabolism (Seoul, Korea) · 2021Article
- The gray zone of thyroid nodules: Using a nomogram to provide malignancy risk assessment and guide patient management.Cancer medicine · 2021Article
- TSH Level and Risk of Malignancy in Patients with Bethesda Category IV Thyroid Nodules.Hormones & cancer · 2020Article
- Predictors of malignancy in high-risk indeterminate (TIR3B) cytopathology thyroid nodules.Journal of endocrinological investigation · 2020Observational
- Galectin-3: The Impact on the Clinical Management of Patients with Thyroid Nodules and Future Perspectives.International journal of molecular sciences · 2018Review
- Ultrasonography scoring systems can rule out malignancy in cytologically indeterminate thyroid nodules.Endocrine · 2017Observational
- Article
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study is to develop a new cancer risk score for preoperative assessment of thyroid nodules (TN) trying to reduce unnecessary thyroidectomies. On the basis of a recent meta-analysis of published literature, we assigned a matching value to the clinical (C) and ultrasonographic (U) features of TN with increased malignancy risk (MR). The created "CUT" score derived from "C+U" score, (CU[1-10] ), along with the five-tiered "T" (T[1-5] ), represents the cytologic result of the fine-needle aspiration. The C+U score was prospectively applied to 683 consecutive patients with 705 TN and validated through a ROC curve analysis. The CUT score was correlated with the histopathological diagnoses of 110 surgically resected TN. Fifty-five histologically benign TN had a mean C+U score of 2.4 versus 5.7 of 55 malignant TN (p < 0.001). Three categories were identified: low risk for C+U score ≤2.5 (MR: 9 %), intermediate risk for C+U score ≥2.75 and ≤5 (MR: 38 %), and high risk for C+U score ≥5.25 (MR: 95 %). Sensitivity and specificity were, respectively, 95 and 60 % for a cut-off value >2.5, and 69 and 96 % for >5. The "CUT" score can be easily applied, aiding clinicians in the evaluation of TN, especially in cases with indeterminate or repeated non-diagnostic FNA.
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