ArticleJournal of vascular surgery2016
Sedentary behavior is associated with impaired biomarkers in claudicants.
Article in Journal of vascular surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Changes in vascular and inflammatory biomarkers after exercise rehabilitation in patients with symptomatic peripheral artery disease.Journal of vascular surgery · 2019Trial
- Association Between Prolonged Sedentary Time and Elevated High-sensitivity C-reactive Protein Among Korean Adults Aged 65 Years or Older: KNHANES 2022.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2026Article
- Association Between Occupational Sitting With High Sensitivity C-Reactive Protein: The Jackson Heart Study.American journal of lifestyle medicine · 2025Article
- From MASLD to PAD: Looking for Cardiovascular Disease Starting from Metabolic Status.Medicina (Kaunas, Lithuania) · 2024Review
- Skeletal muscle desmin alterations following revascularization in peripheral artery disease claudicants.Scientific reports · 2024Article
- Association between physical activity performed at different intensities and cardiovascular health in patients with peripheral artery disease: an observational study.Einstein (Sao Paulo, Brazil) · 2024Observational
- The effects of sedentary behaviour on patients with peripheral arterial Disease: A systematic review.Preventive medicine reports · 2023Review
- Association between lipoprotein(a) and peripheral arterial disease in coronary artery bypass grafting patients.Clinical cardiology · 2023Article
- The Role of Neutrophils in Lower Limb Peripheral Artery Disease: State of the Art and Future Perspectives.International journal of molecular sciences · 2023Review
- Impact of the COVID-19 pandemic on health lifestyle in patients with peripheral artery disease: A cross-sectional study.Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing · 2022Article
- Detrimental effects of physical inactivity on peripheral and brain vasculature in humans: Insights into mechanisms, long-term health consequences and protective strategies.Frontiers in physiology · 2022Review
- Review
- The Length and Number of Sedentary Bouts Predict Fibrinogen Levels in Postmenopausal Women.International journal of environmental research and public health · 2020Article
- Factors Associated with Sedentary Behavior in Patients with Intermittent Claudication.European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTime spent in sedentary behavior has been associated with worse inflammation and cardiometabolic biomarkers in various populations. However, the association between time spent in sedentary behavior and biomarkers remains unknown in patients with intermittent claudication. The aim of the current study was to analyze the relationship between sedentary behavior and inflammatory and cardiometabolic biomarkers in patients with symptomatic peripheral arterial disease (PAD).
methodsThe sample included 297 patients with intermittent claudication. Sedentary behavior was assessed using a step activity monitor. Biomarkers of inflammation, oxidative stress, lipid profile, insulin resistance, and endogenous fibrinolysis were assessed. Demographic data, body mass index, physical activity status, and measures of severity of PAD (ankle-brachial index, peak walking time, and ischemic window) also were obtained.
resultsTime spent in sedentary behavior was related with high-sensitivity C-reactive protein (b = 0.187; P = .005), glucose (b = 0.238; P < .001), fibrinogen (b = 0.167; P = .017), plasminogen activator inhibitor 1 activity (b = 0.143; P = .036), and high-density lipoprotein cholesterol (b = -0.133; P = .029). After adjustment for sex, age, physical activity status, body mass index, and severity of PAD, sedentary behavior remained related with high-sensitivity C-reactive protein (b = 0.170; P = .015), glucose (b = 0.178; P = .004), fibrinogen (b = 0.189; P = .010), and high-density lipoprotein cholesterol (b = -0.128; P = .032).
conclusionsTime spent in sedentary activities was associated with worse inflammatory and cardiometabolic profile in patients with intermittent claudication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.