ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2015
Molecular epidemiology and characterization of multiple drug-resistant (MDR) clinical isolates of Acinetobacter baumannii.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 77 citations in OpenAlex.
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- Molecular Epidemiology and MLST-Based Typing of Pandrug-ResistantIranian journal of pathology · 2025Article
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- Population pharmacokinetics and humanized dosage regimens matching the peak, area, trough, and range of amikacin plasma concentrations in immune-competent murine bloodstream and lung infection models.Antimicrobial agents and chemotherapy · 2024Article
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- Dynamic monitoring of neutrophil/lymphocyte ratio, APACHE II score, and SOFA score predict prognosis and drug resistance in patients withFrontiers in microbiology · 2024Article
- Individual Components of Polymyxin B Modeled via Population Pharmacokinetics to Design Humanized Dosage Regimens for a Bloodstream and Lung Infection Model in Immune-Competent Mice.Antimicrobial agents and chemotherapy · 2023Article
- Extended-Spectrum β-Lactamases (ESBL) Producing Bacteria in Animals.Antibiotics (Basel, Switzerland) · 2023Review
- Penicillin Binding Protein 7/8 Is a Potential Drug Target in Carbapenem-Resistant Acinetobacter baumannii.Antimicrobial agents and chemotherapy · 2023Article
- Acinetobacter nosocomialis Causes as Severe Disease as Acinetobacter baumannii in Northeast Thailand: Underestimated Role of A. nosocomialis in Infection.Microbiology spectrum · 2022Article
- Antibiotic resistance and carriage class I integron in clinical isolates of Acinetobacter baumannii from Al Muthanna, Iraq.The Journal of antibiotics · 2022Article
- Molecular Epidemiology of Clinical Carbapenem-ResistantTropical medicine and infectious disease · 2022Article
- Molecular Characterization of ESBLs and QnrS Producers From SelectedMicrobiology insights · 2022Article
- Virulence Characteristics of Biofilm-FormingMicroorganisms · 2021Article
- Comparative analysis of carbapenemases, RND family efflux pumps and biofilm formation potential among Acinetobacter baumannii strains with different carbapenem susceptibility.BMC infectious diseases · 2021Article
- Analysis ofInternational journal of molecular sciences · 2021Article
- Molecular Epidemiology and Mechanisms of Carbapenem-ResistantInfection and drug resistance · 2021Article
- Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesThe aim of this study was to identify the genetic relatedness of multiple drug-resistant (MDR) Acinetobacter baumannii clinical isolates recovered from a hospital in Los Angeles.
methodsTwenty-one MDR A. baumannii isolates were collected and their antibiotic susceptibilities determined according to Clinical and Laboratory Standards Institute guidelines. Genes coding for antibiotic resistance were identified by PCR, and their identities were confirmed by DNA sequencing. Clonal relationships were studied by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST).
resultsMDR consistently correlated with the presence of oxacillinases, mostly in the form of the plasmid-mediated OXA-23 enzyme, which was detected in 12 (57.1%) isolates. GES-type carbapenemases were found in 20 (95.2%) strains, AAC in all 21 (100%) strains, and PER in seven (33.3%) strains, and ISAba1 was detected in 16 (76.2%) isolates. The association between ISAba1 and resistance genes confirms insertion elements as a source of β-lactamase production. Of the 21 clinical isolates, five were found to be related to sequence type 1 (ST1) and 16 to ST2, as analyzed by MLST. PFGE demonstrated that the majority of clinical isolates were highly related (>85%).
conclusionsThis study supports a more complete understanding of genotyping of antibiotic resistance for better assessment of MDR strain transmission.
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