ArticleToxicological sciences : an official journal of the Society of Toxicology2016
Elevated Lifetime Lead Exposure Impedes Osteoclast Activity and Produces an Increase in Bone Mass in Adolescent Mice.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The Role of Metals and Trace Elements in the Pathogenesis of Osteoarthritis and Other Rheumatic Diseases.International journal of molecular sciences · 2026Review
- Unveiling the Mechanisms of Bone Marrow Toxicity Induced by Lead Acetate Exposure.Biological trace element research · 2024Article
- The influence of adult urine lead exposure on bone mineral densit: NHANES 2015-2018.Frontiers in endocrinology · 2024Article
- Lead induced differences in bone properties in osteocalcin +/+ and -/- female mice.Bone reports · 2023Article
- The Abundance of Trace Elements in Human Bone Relative to Bone Type and Bone Pathology.GeoHealth · 2022Article
- The Association between Lead Exposure and Bone Mineral Density in Childhood and Adolescence: Results from NHANES 1999-2006 and 2011-2018.Nutrients · 2022Article
- Differential fat accumulation in early adulthood according to adolescent-BMI and heavy metal exposure.New directions for child and adolescent development · 2022Article
- Bone manganese is a sensitive biomarker of ongoing elevated manganese exposure, but does not accumulate across the lifespan.Environmental research · 2022Article
- Tungsten Increases Sex-Specific Osteoclast Differentiation in Murine Bone.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Adipotropic effects of heavy metals and their potential role in obesity.Faculty reviews · 2021Review
- Allicin Alleviates Lead-Induced Bone Loss by Preventing Oxidative Stress and Osteoclastogenesis Via SIRT1/FOXO1 Pathway in Mice.Biological trace element research · 2021Article
- CTD Anatomy: analyzing chemical-induced phenotypes and exposures from an anatomical perspective, with implications for environmental health studies.Current research in toxicology · 2021Article
- Long-Term in Situ Reduction in Soil Lead Bioavailability Measured in a Mouse Model.Environmental science & technology · 2018Article
- Study on the relationship between age and the concentrations of heavy metal elements in human bone.Annals of translational medicine · 2018Article
- Nuclear receptor and VEGF pathways for gene-blood lead interactions, on bone mineral density, in Korean smokers.PloS one · 2018Article
- Environmental Factors Impacting Bone-Relevant Chemokines.Frontiers in endocrinology · 2017Article
- Stunting is associated with blood lead concentration among Bangladeshi children aged 2-3 years.Environmental health : a global access science source · 2016Article
- Perinatal Lead Exposure Alters Gut Microbiota Composition and Results in Sex-specific Bodyweight Increases in Adult Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
Corrections and comments
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4 authors.
Funding
Abstract
The heavy metal lead (Pb) has a deleterious effect on skeletal health. Because bone mass is maintained through a balance of bone formation and resorption, it is important to understand the effect of Pb levels on osteoblastic and osteoclastic activity. Pb exposure is associated with low bone mass in animal models and human populations; however, the correlation between Pb dosing and corresponding bone mass has been poorly explored. Thus, mice were exposed to increasing Pb and at higher levels (500 ppm), there was unexpectedly an increase in femur-tibial bone mass by 3 months of age. This is contrary to several studies alluded to earlier. Increased bone volume (BV) was accompanied by a significant increase in cortical thickness of the femur and trabecular bone that extended beyond the epiphyseal area into the marrow cavity. Subsequent evaluations revealed an increase in osteoclast numbers with high Pb exposure, but a deficiency in osteoclastic activity. These findings were substantiated by observed increases in levels of the resorption-altering hormones calcitonin and estrogen. In addition we found that pro-osteoclastic nuclear factor-kappa beta (NF-κB) pathway activity was dose dependently elevated with Pb, both in vivo and in vitro. However, the ability of osteoclasts to resorb bone was depressed in the presence of Pb in media and within test bone wafers. These findings indicate that exposure to high Pb levels disrupts early life bone accrual that may involve a disruption of osteoclast activity. This study accentuates the dose dependent variation in Pb exposure and consequent effects on skeletal health.
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