Evidence map›Paper›PMID 26518021›Full record

Trial reportBreast cancer research and treatment2015

A randomized controlled trial of cognitive-behavioral stress management in breast cancer: survival and recurrence at 11-year follow-up.

Jamie M Stagl, Suzanne C Lechner, Charles S Carver, Laura C Bouchard, Lisa M Gudenkauf, Devika R Jutagir, Alain Diaz, Qilu Yu, Bonnie B Blomberg, Gail Ironson and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Breast cancer research and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 9 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 9 syntheses or guidelines pooled it, 136 citations in OpenAlex.

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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jamie M StaglThe Center for Psychiatric Oncology and Behavioral Sciences, Massachusetts General Hospital Cancer Center, 55 Fruit Street, Yawkey Suite 10B, Boston, MA, 02114, USA. jstagl@mgh.harvard.edu.
Suzanne C LechnerDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1120 N.W. 14th Street, Miami, FL, 33136, USA.
Charles S CarverSylvester Cancer Center, University of Miami Miller School of Medicine, 1475 N.W. 12th Avenue, Miami, FL, 33136, USA.
Laura C BouchardDepartment of Psychology, University of Miami, 5665 Ponce De Leon Blvd, Coral Gables, FL, 33146, USA.
Lisa M GudenkaufDepartment of Psychology, University of Miami, 5665 Ponce De Leon Blvd, Coral Gables, FL, 33146, USA.
Devika R JutagirDepartment of Psychology, University of Miami, 5665 Ponce De Leon Blvd, Coral Gables, FL, 33146, USA.
Alain DiazDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, 1600 N.W. 10th Avenue, Miami, FL, 33136, USA.
Qilu YuWestat, 1600 Research Boulevard, Rockville, MD, 20850, USA.
Bonnie B BlombergSylvester Cancer Center, University of Miami Miller School of Medicine, 1475 N.W. 12th Avenue, Miami, FL, 33136, USA.
Gail IronsonDepartment of Psychology, University of Miami, 5665 Ponce De Leon Blvd, Coral Gables, FL, 33146, USA.
Stefan GlückCelgene Corporation, Summit, NJ, 07901, USA.
Michael H AntoniDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1120 N.W. 14th Street, Miami, FL, 33136, USA.
University of Miami · USMassachusetts General Hospital · USSylvester Comprehensive Cancer Center · USWestat (United States) · US

Funding

FACILITATING POSITIVE ADAPTATION TO BREAST CANCERR01CA064710 · NCI · UNIVERSITY OF MIAMI CORAL GABLES · PI ANTONI, MICHAEL HOWARD · 1994 to 2010
$4.2M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENCI NIH HHS R01 CA064710NCI NIH HHS R01-CA-064710
6 · The paper itself

Abstract

Non-metastatic breast cancer patients often experience psychological distress which may influence disease progression and survival. Cognitive-behavioral stress management (CBSM) improves psychological adaptation and lowers distress during breast cancer treatment and long-term follow-ups. We examined whether breast cancer patients randomized to CBSM had improved survival and recurrence 8-15 years post-enrollment. From 1998 to 2005, women (N = 240) 2-10 weeks post-surgery for non-metastatic Stage 0-IIIb breast cancer were randomized to a 10-week, group-based CBSM intervention (n = 120) or a 1-day psychoeducational seminar control (n = 120). In 2013, 8-15 years post-study enrollment (11-year median), recurrence and survival data were collected. Cox Proportional Hazards Models and Weibull Accelerated Failure Time tests were used to assess group differences in all-cause mortality, breast cancer-specific mortality, and disease-free interval, controlling for biomedical confounders. Relative to the control, the CBSM group was found to have a reduced risk of all-cause mortality (HR = 0.21; 95 % CI [0.05, 0.93]; p = .040). Restricting analyses to women with invasive disease revealed significant effects of CBSM on breast cancer-related mortality (p = .006) and disease-free interval (p = .011). CBSM intervention delivered post-surgery may provide long-term clinical benefit for non-metastatic breast cancer patients in addition to previously established psychological benefits. Results should be interpreted with caution; however, the findings contribute to the limited evidence regarding physical benefits of psychosocial intervention post-surgery for non-metastatic breast cancer. Additional research is necessary to confirm these results and investigate potential explanatory mechanisms, including physiological pathways, health behaviors, and treatment adherence changes.

Indexed as

Cognitive Behavioral TherapyAdaptation, PsychologicalAdultBiomarkers, TumorBreast NeoplasmsCause of DeathCognitionCombined Modality TherapyDisease ManagementFemaleFollow-Up StudiesHumansMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingProportional Hazards ModelsBiomarkers, TumorBehavior therapyBreast cancerBreast neoplasmCognitive therapyRecurrenceSurvival

Identifiers

PMID26518021
PMCPMC5752103
OpenAlexW1906194972

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.