ArticleDevelopmental biology2016
The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation.
Article in Developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 44 citations in OpenAlex.
- Dishevelled-mediated clustering stabilizes Frizzled6 and Vangl2 to establish planar cell polarity in the mammalian skin.Science advances · 2026Article
- Melatonin Regulates the Proliferation of Liaoning Cashmere Goat Skin Fibroblasts via the lncRNA16913.1-chi-miR-195-5p-FZD6 Axis.Animals : an open access journal from MDPI · 2026Article
- A novel, PCP-dependent tissue organising principle coordinating morphogenesis between embryonic skin epidermal layers.Journal of anatomy · 2026Article
- Progressive correction of auditory hair cell orientation in the absence of core planar cell polarity and GPR156 signaling.Development (Cambridge, England) · 2026Article
- Planar cell polarity emerges through polarized accumulation of Wnt11.Science advances · 2026Article
- The Rho GTPase regulator ARHGEF3 orchestrates hair placode budding by coordinating cell fate and P-cadherin patterning in mice.PLoS biology · 2026Article
- Technical Considerations for Detecting Protein-Protein Interactions Using Proximity Ligation Assay.Journal of proteome research · 2025Article
- Development and regeneration of Merkel cells.Current topics in developmental biology · 2025Review
- ARHGEF3 Regulates Hair Follicle Morphogenesis.bioRxiv : the preprint server for biology · 2024Article
- Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex.Development (Cambridge, England) · 2024Article
- Evaluating Planar Cell Polarity in the Developing Mouse Epidermis.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Region-specific reversal of epidermal planar polarity in the rosette fancy mouse.Development (Cambridge, England) · 2023Article
- Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development.Development (Cambridge, England) · 2022Article
- Transcriptional Characteristics Showed That miR-144-y/FOXO3 Participates in Embryonic Skin and Feather Follicle Development in Zhedong White Goose.Animals : an open access journal from MDPI · 2022Article
- The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development.Development (Cambridge, England) · 2022Article
- Vangl2 Promotes Hematopoietic Stem Cell Expansion.Frontiers in cell and developmental biology · 2022Article
- Planar cell polarity proteins determine basal cell height in the later stage embryonic mouse epidermis'.Wellcome open research · 2022Article
- G protein-coupled receptors in cochlea: Potential therapeutic targets for hearing loss.Frontiers in molecular neuroscience · 2022Review
- Celsr1 and Celsr2 exhibit distinct adhesive interactions and contributions to planar cell polarity.Frontiers in cell and developmental biology · 2022Article
- Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure.Developmental biology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In mammals, hair follicles cover most of the body surface and exhibit precise and stereotyped orientations relative to the body axes. Follicle orientation is controlled by the planar cell polarity (PCP; or, more generally, tissue polarity) system, as determined by the follicle mis-orientation phenotypes observed in mice with PCP gene mutations. The present study uses conditional knockout alleles of the PCP genes Frizzled6 (Fz6), Vangl1, and Vangl2, together with a series of Cre drivers to interrogate the spatio-temporal domains of PCP gene action in the developing mouse epidermis required for follicle orientation. Fz6 is required starting between embryonic day (E)11.5 and E12.5. Eliminating Fz6 in either the anterior or the posterior halves of the embryo or in either the feet or the torso leads to follicle mis-orientation phenotypes that are limited to the territories associated with Fz6 loss, implying either that PCP signaling is required for communicating polarity information on a local but not a global scale, or that there are multiple independent sources of global polarity information. Eliminating Fz6 in most hair follicle cells or in the inter-follicular epidermis at E15.5 suggests that PCP signaling in developing follicles is not required to maintain their orientation. The asymmetric arrangement of Merkel cells around the base of each guard hair follicle dependents on Fz6 expression in the epidermis but not in differentiating Merkel cells. These experiments constrain current models of PCP signaling and the flow of polarity information in mammalian skin.
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