Evidence map›Paper›PMID 26517953›Full record

ArticleExperimental gerontology2015

Prolonged performance of a high repetition low force task induces bone adaptation in young adult rats, but loss in mature rats.

Vicky S Massicotte, Nagat Frara, Michele Y Harris, Mamta Amin, Christine K Wade, Steven N Popoff, Mary F Barbe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental gerontology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. PrPJournal of cachexia, sarcopenia and muscle · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vicky S MassicotteDepartment of Anatomy and Cell Biology, Temple University School of Medicine, 3500 North Broad St., Philadelphia, PA 19140, USA.
Nagat FraraDepartment of Anatomy and Cell Biology, Temple University School of Medicine, 3500 North Broad St., Philadelphia, PA 19140, USA.
Michele Y HarrisDepartment of Anatomy and Cell Biology, Temple University School of Medicine, 3500 North Broad St., Philadelphia, PA 19140, USA.
Mamta AminDepartment of Anatomy and Cell Biology, Temple University School of Medicine, 3500 North Broad St., Philadelphia, PA 19140, USA.
Christine K WadeDepartment of Physical Therapy, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Steven N PopoffDepartment of Anatomy and Cell Biology, Temple University School of Medicine, 3500 North Broad St., Philadelphia, PA 19140, USA.
Mary F BarbeDepartment of Anatomy and Cell Biology, Temple University School of Medicine, 3500 North Broad St., Philadelphia, PA 19140, USA; Department of Physical Therapy, Temple University, Philadelphia, PA 19140, USA. Electronic address: mary.barbe@temple.edu.

Funding

Biomarkers of Tissue Tolerance and Behavior in a Rat ModelR01AR056019 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI BARBE, MARY F · 2009 to 2025
$7.3M
High-resolution ex vivo micro-computerized tomography systemS10RR026727 · NCRR · TEMPLE UNIV OF THE COMMONWEALTH · PI BARBE, MARY F · 2010 to 2010
$308k
NCRR NIH HHS S10 RR026727NIAMS NIH HHS AR056019NIAMS NIH HHS R01 AR056019
6 · The paper itself

Abstract

We have shown that prolonged repetitive reaching and grasping tasks lead to exposure-dependent changes in bone microarchitecture and inflammatory cytokines in young adult rats. Since aging mammals show increased tissue inflammatory cytokines, we sought here to determine if aging, combined with prolonged performance of a repetitive upper extremity task, enhances bone loss. We examined the radius, forearm flexor muscles, and serum from 16 mature (14-18 months of age) and 14 young adult (2.5-6.5 months of age) female rats after performance of a high repetition low force (HRLF) reaching and grasping task for 12 weeks. Young adult HRLF rats showed enhanced radial bone growth (e.g., increased trabecular bone volume, osteoblast numbers, bone formation rate, and mid-diaphyseal periosteal perimeter), compared to age-matched controls. Mature HRLF rats showed several indices of radial bone loss (e.g., decreased trabecular bone volume, and increased cortical bone thinning, porosity, resorptive spaces and woven bone formation), increased osteoclast numbers and inflammatory cytokines, compared to age-matched controls and young adult HRLF rats. Mature rats weighed more yet had lower maximum reflexive grip strength, than young adult rats, although each age group was able to pull at the required reach rate (4 reaches/min) and required submaximal pulling force (30 force-grams) for a food reward. Serum estrogen levels and flexor digitorum muscle size were similar in each age group. Thus, mature rats had increased bone degradative changes than in young adult rats performing the same repetitive task for 12 weeks, with increased inflammatory cytokine responses and osteoclast activity as possible causes.

Indexed as

AgingAnimalsBone and BonesCumulative Trauma DisordersCytokinesDisease Models, AnimalEstrogensFemaleMusculoskeletal DiseasesOsteoblastsOsteoclastsRatsRats, Sprague-DawleyX-Ray MicrotomographyCytokinesEstrogensAgingBoneInflammationMicroCTMusculoskeletalRadiusRepetitive strain injury

Identifiers

PMID26517953
PMCPMC4655973

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.