ArticlePloS one2015
Orally-Induced Intestinal CD4+ CD25+ FoxP3+ Treg Controlled Undesired Responses towards Oral Antigens and Effectively Dampened Food Allergic Reactions.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Identifying gene network patterns and associated cellular immune responses in children with or without nut allergy.The World Allergy Organization journal · 2022Article
- AIT: New Avenues in Allergen Immunotherapy.Handbook of experimental pharmacology · 2022Article
- OVA-Experienced CD4International journal of molecular sciences · 2021Article
- New Insights in Therapy for Food Allergy.Foods (Basel, Switzerland) · 2021Review
- Mucosal Immunoregulatory Properties ofFrontiers in immunology · 2021Article
- Antigen-Specific Regulatory T Cell Therapy in Autoimmune Diseases and Transplantation.Frontiers in immunology · 2021Review
- The gut microbiota, environmental factors, and links to the development of food allergy.Clinical and molecular allergy : CMA · 2020Review
- Recent advances in mechanisms of food allergy and anaphylaxis.F1000Research · 2020Review
- Mouse strain differences in response to oral immunotherapy for peanut allergy.Immunity, inflammation and disease · 2019Article
- Non-digestible oligosaccharides scFOS/lcFOS facilitate safe subcutaneous immunotherapy for peanut allergy.Clinical and molecular allergy : CMA · 2019Article
- Mechanism for initiation of food allergy: Dependence on skin barrier mutations and environmental allergen costimulation.The Journal of allergy and clinical immunology · 2018Article
- The role of basophils as innate immune regulatory cells in allergy and immunotherapy.Human vaccines & immunotherapeutics · 2018Review
- Oral Tolerance Development and Maintenance.Immunology and allergy clinics of North America · 2018Review
- Regulatory Immune Mechanisms in Tolerance to Food Allergy.Frontiers in immunology · 2018Review
- Article
- B-FAHF-2 plus oral immunotherapy (OIT) is safer and more effective than OIT alone in a murine model of concurrent peanut/tree nut allergy.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Article
- Molecular and cellular mechanisms of food allergy and food tolerance.The Journal of allergy and clinical immunology · 2016Review
- Helicobacter pylori-Mediated Protection from Allergy Is Associated with IL-10-Secreting Peripheral Blood Regulatory T Cells.Frontiers in immunology · 2016Article
- Biomarkers in oral immunotherapy.Journal of Zhejiang University. Science. BReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The induction of peripheral tolerance may constitute a disease-modifying treatment for allergic patients. We studied how oral immunotherapy (OIT) with milk proteins controlled allergy in sensitized mice (cholera toxin plus milk proteins) upon exposure to the allergen. Symptoms were alleviated, skin test was negativized, serum specific IgE and IgG1 were abrogated, a substantial reduction in the secretion of IL-5 and IL-13 by antigen-stimulated spleen cells was observed, while IL-13 gene expression in jejunum was down-regulated, and IL-10 and TGF-β were increased. In addition, we observed an induction of CD4+CD25+FoxP3+ cells and IL-10- and TGF-β-producing regulatory T cells in the lamina propria. Finally, transfer experiments confirmed the central role of these cells in tolerance induction. We demonstrated that the oral administration of milk proteins pre- or post-sensitization controlled the Th2-immune response through the elicitation of mucosal IL-10- and TGF-β-producing Tregs that inhibited hypersensitivity symptoms and the allergic response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.