Evidence map›Paper›PMID 26517867›Full record

Trial reportPloS one2015

Effects of High-Intensity Interval Training versus Continuous Training on Physical Fitness, Cardiovascular Function and Quality of Life in Heart Failure Patients.

Nathalie M M Benda, Joost P H Seeger, Guus G C F Stevens, Bregina T P Hijmans-Kersten, Arie P J van Dijk, Louise Bellersen, Evert J P Lamfers, Maria T E Hopman, Dick H J Thijssen

Registry-linked trialAbstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05681065 (Affective Based Integrated Care for Better Quality of Life), which is not on this map. Cited by 44 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05681065 nacompletednot on this mapstarted 2021, after this paper: background citation

Affective Based Integrated Care for Better Quality of Life (TeNDER).Pilot Implementation. Site 1: Primary Care Madrid, Spain.

TypeinterventionalSponsorGerencia de Atención Primaria, MadridRan2021 to 2023Enrolled534ConditionsChronic DiseaseArmsTeNDER tool
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 16 syntheses or guidelines pooled it.

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  3. Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023
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  4. Exercise interventions for adults after liver transplantation.The Cochrane database of systematic reviews · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nathalie M M BendaRadboud university medical center, Radboud Institute for Health Sciences, Department of Physiology, Nijmegen, the Netherlands.
Joost P H SeegerRadboud university medical center, Radboud Institute for Health Sciences, Department of Physiology, Nijmegen, the Netherlands; Liverpool John Moores University, Research Institute for Sport and Exercise Sciences, Liverpool, United Kingdom.
Guus G C F StevensRadboud university medical center, Radboud Institute for Health Sciences, Department of Physiology, Nijmegen, the Netherlands.
Bregina T P Hijmans-KerstenRadboud university medical center, Radboud Institute for Health Sciences, Department of Physiology, Nijmegen, the Netherlands.
Arie P J van DijkRadboud university medical center, Radboud Institute for Health Sciences, Department of Cardiology, Nijmegen, the Netherlands.
Louise BellersenRadboud university medical center, Radboud Institute for Health Sciences, Department of Cardiology, Nijmegen, the Netherlands.
Evert J P LamfersCanisius-Wilhelmina Hospital, Department of Cardiology, Nijmegen, the Netherlands.
Maria T E HopmanRadboud university medical center, Radboud Institute for Health Sciences, Department of Physiology, Nijmegen, the Netherlands.
Dick H J ThijssenRadboud university medical center, Radboud Institute for Health Sciences, Department of Physiology, Nijmegen, the Netherlands; Liverpool John Moores University, Research Institute for Sport and Exercise Sciences, Liverpool, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPhysical fitness is an important prognostic factor in heart failure (HF). To improve fitness, different types of exercise have been explored, with recent focus on high-intensity interval training (HIT). We comprehensively compared effects of HIT versus continuous training (CT) in HF patients NYHA II-III on physical fitness, cardiovascular function and structure, and quality of life, and hypothesize that HIT leads to superior improvements compared to CT.

methodsTwenty HF patients (male:female 19:1, 64±8 yrs, ejection fraction 38±6%) were allocated to 12-weeks of HIT (10*1-minute at 90% maximal workload-alternated by 2.5 minutes at 30% maximal workload) or CT (30 minutes at 60-75% of maximal workload). Before and after intervention, we examined physical fitness (incremental cycling test), cardiac function and structure (echocardiography), vascular function and structure (ultrasound) and quality of life (SF-36, Minnesota living with HF questionnaire (MLHFQ)).

resultsTraining improved maximal workload, peak oxygen uptake (VO2peak) related to the predicted VO2peak, oxygen uptake at the anaerobic threshold, and maximal oxygen pulse (all P<0.05), whilst no differences were present between HIT and CT (N.S.). We found no major changes in resting cardiovascular function and structure. SF-36 physical function score improved after training (P<0.05), whilst SF-36 total score and MLHFQ did not change after training (N.S.).

conclusionTraining induced significant improvements in parameters of physical fitness, although no evidence for superiority of HIT over CT was demonstrated. No major effect of training was found on cardiovascular structure and function or quality of life in HF patients NYHA II-III.

trial registrationNederlands Trial Register NTR3671.

Indexed as

AgedExercise TherapyFemaleHeart FailureHumansMaleMiddle AgedPhysical FitnessQuality of LifeTreatment Outcome

Identifiers

PMID26517867
PMCPMC4627811

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.