ArticleInternational journal of environmental research and public health2015
Threshold Dose of Three Types of Quantum Dots (QDs) Induces Oxidative Stress Triggers DNA Damage and Apoptosis in Mouse Fibroblast L929 Cells.
Article in International journal of environmental research and public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A Review of in vivo Toxicity of Quantum Dots in Animal Models.International journal of nanomedicine · 2023Review
- Feasibility of Silicon Quantum Dots as a Biomarker for the Bioimaging of Tear Film.Nanomaterials (Basel, Switzerland) · 2022Article
- Assessment of the Toxicity of Quantum Dots through Biliometric Analysis.International journal of environmental research and public health · 2021Article
- Article
- CdSe/ZnS Core-Shell-Type Quantum Dot Nanoparticles Disrupt the Cellular Homeostasis in Cellular Blood-Brain Barrier Models.International journal of molecular sciences · 2021Article
- Quantum Dots: An Emerging Tool for Point-of-Care Testing.Micromachines · 2020Review
- Mixed Mercaptocarboxylic Acid Shells Provide Stable Dispersions of InPZnS/ZnSe/ZnS Multishell Quantum Dots in Aqueous Media.Nanomaterials (Basel, Switzerland) · 2020Article
- Revisiting the cytotoxicity of quantum dots: an in-depth overview.Biophysical reviews · 2020Review
- ToxTracker Reporter Cell Lines as a Tool for Mechanism-Based (geno)Toxicity Screening of Nanoparticles-Metals, Oxides and Quantum Dots.Nanomaterials (Basel, Switzerland) · 2020Article
- Cadmium telluride quantum dot-exposed human bronchial epithelial cells: a further study of the cellular response by proteomics.Toxicology research · 2019Article
- Transcriptome Profile Alteration with Cadmium Selenide/Zinc Sulfide Quantum Dots inBiomolecules · 2019Article
- An In Vitro Investigation of Cytotoxic Effects of InP/Zns Quantum Dots with Different Surface Chemistries.Nanomaterials (Basel, Switzerland) · 2019Article
- Review
- Cytotoxicity investigations of biogenic tellurium nanorods towards PC12 cell line.IET nanobiotechnology · 2018Article
- Live-stream characterization of cadmium-induced cell death using visible CdTe-QDs.Scientific reports · 2018Article
- Encapsulation of Cadmium Selenide Nanocrystals in Biocompatible Nanotubes: DFT Calculations, X-ray Diffraction Investigations, and Confocal Fluorescence Imaging.ChemistryOpen · 2018Article
- Dysfunction of various organelles provokes multiple cell death after quantum dot exposure.International journal of nanomedicine · 2018Review
- Parallel comparative studies on toxicity of quantum dots synthesized and surface engineered with different methods in vitro and in vivo.International journal of nanomedicine · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although it has been reported that fluorescent quantum dots (QDs) have obvious acute toxic effects in vitro, their toxic effects at low doses or threshold doses are still unknown. Therefore, we evaluated the biological histocompatibility and in vitro toxicity of three types of QDs at threshold doses. Also, we compared the toxic effects of QDs with different raw chemical compositions and sizes. The results showed that low concentrations of QDs (≤7 μg/mL) had no obvious effect on cell viability and cell membrane damage, oxidative damage, cell apoptosis or DNA damage. However, QD exposure led to a significant cytotoxicity at higher doses (≥14 μg/mL) and induced abnormal cellular morphology. In addition, when comparing the three types of QDs, 2.2 nm CdTe QDs exposure showed a significantly increased proportion of apoptotic cells and significant DNA damage, suggesting that size and composition contribute to the toxic effects of QDs. Based on these discussions, it was concluded that the concentration (7 μg/mL) may serve as a threshold level for these three types of QDs only in L929 fibroblasts, whereas high concentrations (above 14 μg/mL) may be toxic, resulting in inhibition of proliferation, induction of apoptosis and DNA damage in L929 fibroblasts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.