ArticleMarine drugs2015
Bioactive Hydantoin Alkaloids from the Red Sea Marine Sponge Hemimycale arabica.
Article in Marine drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Recent Development in Hydantoins, Thiohydantoins, and Selenohydantoins as Anticancer Agents: Structure-activity Relationship and Design Strategies.Mini reviews in medicinal chemistry · 2025Review
- Article
- Synthesis, Absolute Configuration, Biological Profile and Antiproliferative Activity of New 3,5-Disubstituted Hydantoins.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Cyclodipeptide oxidase is an enzyme filament.Nature communications · 2024Article
- Anti-Candidal Marine Natural Products: A Review.Journal of fungi (Basel, Switzerland) · 2023Review
- Hemimycale Arabica Induced Non-Cytotoxic Anti-Migratory Activity in Hepatocellular Carcinoma In Vitro.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Hemimycalins C-E; Cytotoxic and Antimicrobial Alkaloids with Hydantoin and 2-Iminoimidazolidin-4-one Backbones from the Red Sea Marine SpongeMarine drugs · 2021Article
- Bioactive natural products from marine sponges belonging to family Hymedesmiidae.RSC advances · 2021Review
- Synthesis and Antiplasmodial Activity of Novel Bioinspired Imidazolidinedione Derivatives.Biomolecules · 2020Article
- Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa.Marine drugs · 2020Review
- Marine sponges of the genusActa pharmaceutica Sinica. B · 2019Review
- Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials.Marine drugs · 2017Review
- Anticancer Effects of the Marine SpongeEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Cytotoxic Compounds from the Saudi Red Sea Sponge Xestospongia testudinaria.Marine drugs · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the course of our continuing efforts to identify bioactive secondary metabolites from Red Sea marine invertebrates, we have investigated the sponge Hemimycale arabica. The antimicrobial fraction of an organic extract of the sponge afforded two new hydantoin alkaloids, hemimycalins A and B (2 and 3), together with the previously reported compound (Z)-5-(4-hydroxybenzylidene)imidazolidine-2,4-dione (1). The structures of the compounds were determined by extensive 1D and 2D NMR (COSY, HSQC and HMBC) studies and high-resolution mass spectral determinations. Hemimycalins A (2) and B (3) represent the first examples of the natural N-alkylated hydantoins from the sponge Hemimycale arabica. Compounds 1-3 displayed variable antimicrobial activities against E. coli, S. aureus, and C. albicans. In addition, compound 1 displayed moderate antiproliferative activity against the human cervical carcinoma (HeLa) cell line. These findings provide further insight into the chemical diversity as well as the biological activity of this class of compounds.
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