Evidence map›Paper›PMID 26516838›Full record

ReviewInternational journal of molecular sciences2015

Perturbation of Brain Oscillations after Ischemic Stroke: A Potential Biomarker for Post-Stroke Function and Therapy.

Gratianne Rabiller, Ji-Wei He, Yasuo Nishijima, Aaron Wong, Jialing Liu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Brain Oscillatory Modes as a Proxy of Stroke Recovery.Neurorehabilitation and neural repair · 2025
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gratianne RabillerDepartment of Neurological Surgery, University of California at San Francisco and Department of Veterans Affairs Medical Center, 1700 Owens Street, San Francisco, CA 94158, USA. gratianne.rabiller@gmail.com.
Ji-Wei HeDepartment of Neurological Surgery, University of California at San Francisco and Department of Veterans Affairs Medical Center, 1700 Owens Street, San Francisco, CA 94158, USA. jiwei.he@ucsf.edu.
Yasuo NishijimaDepartment of Neurological Surgery, University of California at San Francisco and Department of Veterans Affairs Medical Center, 1700 Owens Street, San Francisco, CA 94158, USA. nishijima_yasu@yahoo.co.jp.
Aaron WongDepartment of Neurological Surgery, University of California at San Francisco and Department of Veterans Affairs Medical Center, 1700 Owens Street, San Francisco, CA 94158, USA. aaronwong95@gmail.com.
Jialing LiuDepartment of Neurological Surgery, University of California at San Francisco and Department of Veterans Affairs Medical Center, 1700 Owens Street, San Francisco, CA 94158, USA. jialing.liu@ucsf.edu.

Funding

Neuroplasticity after experimental strokeR01NS071050 · NINDS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI LIU, JIALING · 2011 to 2015
$1.6M
Mechanisms underlying Netrin-1-mediated functional recovery after strokeI01RX000655 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI LIU, JIALING · 2012 to 2015
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BLRD VA I01 BX003335NINDS NIH HHS R01 NS071050RRD VA I01 RX000655
6 · The paper itself

Abstract

Brain waves resonate from the generators of electrical current and propagate across brain regions with oscillation frequencies ranging from 0.05 to 500 Hz. The commonly observed oscillatory waves recorded by an electroencephalogram (EEG) in normal adult humans can be grouped into five main categories according to the frequency and amplitude, namely δ (1-4 Hz, 20-200 μV), θ (4-8 Hz, 10 μV), α (8-12 Hz, 20-200 μV), β (12-30 Hz, 5-10 μV), and γ (30-80 Hz, low amplitude). Emerging evidence from experimental and human studies suggests that groups of function and behavior seem to be specifically associated with the presence of each oscillation band, although the complex relationship between oscillation frequency and function, as well as the interaction between brain oscillations, are far from clear. Changes of brain oscillation patterns have long been implicated in the diseases of the central nervous system including ischemic stroke, in which the reduction of cerebral blood flow as well as the progression of tissue damage have direct spatiotemporal effects on the power of several oscillatory bands and their interactions. This review summarizes the current knowledge in behavior and function associated with each brain oscillation, and also in the specific changes in brain electrical activities that correspond to the molecular events and functional alterations observed after experimental and human stroke. We provide the basis of the generations of brain oscillations and potential cellular and molecular mechanisms underlying stroke-induced perturbation. We will also discuss the implications of using brain oscillation patterns as biomarkers for the prediction of stroke outcome and therapeutic efficacy.

Indexed as

Brain WavesAction PotentialsAnimalsBrain IschemiaCortical SynchronizationHumansStrokeaction potentialCBFelectroencephalographyMCAO

Identifiers

PMID26516838
PMCPMC4632818

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.