ArticlePloS one2015
Hypoxia Induces a Prothrombotic State Independently of the Physical Activity.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- The Influence of Environmental Hypoxia on Hemostasis-A Systematic Review.Frontiers in cardiovascular medicine · 2022Pooled it
- Trial
- Thirty Minutes of Hypobaric Hypoxia Provokes Alterations of Immune Response, Haemostasis, and Metabolism Proteins in Human Serum.International journal of molecular sciences · 2017Trial
- Polycythemia Vera, Thrombophilia, CTEPH, Cerebral Venous Sinus Thrombosis and Vertebral Artery Occlusion: A Case-Illustrated Narrative Review of Competing Thrombotic and Hemorrhagic Risks.Life (Basel, Switzerland) · 2026Article
- Chronic Obstructive Pulmonary Disease and COVID-19: The Impact of Hematological Biomarkers on Disease Severity and Outcomes.Journal of clinical medicine · 2025Review
- Inhibition of autophagy in platelets as a therapeutic strategy preventing hypoxia induced thrombosis.Scientific reports · 2025Article
- Risk Assessment and Prevention of Venous Thromboembolism in Critically Ill Patients in Tibet: A Prospective Cohort Study with Historical Controls.Risk management and healthcare policy · 2025Article
- Perioperative considerations in the paediatric patient with congenital and acquired coagulopathy.BJA open · 2024Review
- Coagulation Profile in Neonates with Congenital Heart Disease: A Pilot Study.Medicina (Kaunas, Lithuania) · 2024Article
- Trauma patients have reduced ex vivo flow-dependent platelet hemostatic capacity in a microfluidic model of vessel injury.PloS one · 2024Article
- Blood urea nitrogen to creatinine ratio is associated with in-hospital mortality in critically ill patients with venous thromboembolism: a retrospective cohort study.Frontiers in cardiovascular medicine · 2024Article
- JAK2 Mutation Assessment in Thrombotic Events at Unusual Anatomical Sites: Insights from a High-Altitude Cohort.International journal of general medicine · 2024Article
- Combined endovascular interventions for pulmonary embolism at high altitude in Tibet.Frontiers in cardiovascular medicine · 2024Article
- Chymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse Model.Journal of the American Heart Association · 2023Article
- Coagulation Disorders in Sepsis and COVID-19-Two Sides of the Same Coin? A Review of Inflammation-Coagulation Crosstalk in Bacterial Sepsis and COVID-19.Journal of clinical medicine · 2023Review
- Coagulation abnormalities in children with uncorrected congenital heart defects seen at a teaching hospital in a developing country.PloS one · 2022Article
- A Higher Altitude Is Associated with Increased Incidence of Infections following Primary Total Hip Arthroplasty.Hip & pelvis · 2021Article
- Red blood cell exchange for SARS-CoV-2: A Gemini of therapeutic opportunities.Medical hypotheses · 2020Article
- Emerging patterns of hypercoagulability associated with critical COVID-19: A review.Trends in anaesthesia & critical care · 2020Review
- Hypoxia Modulates Platelet Purinergic Signalling Pathways.Thrombosis and haemostasis · 2020Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoxia (oxygen deprivation) is known to be associated with deep vein thrombosis and venous thromboembolism. We attempted to get a better comprehension of its mechanism by going to high altitude, thereby including the potential contributing role of physical activity. Two groups of 15 healthy individuals were exposed to hypoxia by going to an altitude of 3900 meters, either by climbing actively (active group) or transported passively by cable car (passive group). Both groups were tested for plasma fibrinogen, von Willebrand factor and factor VIII levels, fibrinolysis, thrombin generating capacity, heart rate, oxygen saturation levels and blood pressure. As a control for the passive group, 7 healthy volunteers stayed immobile in bed for 7 days at normoxic conditions. The heart rate increased and oxygen saturation levels decreased with increasing altitude. Fibrinolysis and fibrinogen levels were not affected. Factor VIII and von Willebrand factor levels levels increased significantly in the active group, but not in the passive group. Plasma thrombin generation remained unchanged in both the active and passive group with increasing altitude and during 7 days of immobility in healthy subjects. However, by applying whole blood thrombin generation, we found an increased peak height and endogenous thrombin potential, and a decreased lagtime and time-to-peak with increasing levels of hypoxia in both groups. In conclusion, by applying whole blood thrombin generation we demonstrated that hypoxia causes a prothrombotic state. As thrombin generation in plasma did not increase, our results suggest that the cellular part of the blood is involved in the prothrombotic phenotype induced by hypoxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.