ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2016
Inflammatory hepatocellular adenomas developed in the setting of chronic liver disease and cirrhosis.
Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 54 citations in OpenAlex.
- A β-catenin-activated hepatocellular adenoma with inflammatory features: diagnostic challenges of integrating imaging and biopsy findings.Clinical journal of gastroenterology · 2026Article
- New histopathological terminology for well-differentiated hepatocellular lesions in unusual clinico-pathological scenarios: HCA-like and FNH-like.JHEP reports : innovation in hepatology · 2026Review
- Nonoperative Management of Hepatic Adenomas: A Review.Journal of gastrointestinal cancer · 2026Review
- A Case Report of an Inflammatory Hepatocellular Adenoma Mimicking Hepatocellular Carcinoma in a Patient with Alcoholic Cirrhosis.Current medical imaging · 2026Article
- Hepatocellular Adenoma With Hepatocyte Nuclear Factor-1 Alpha (HNF-1α) Mutation: A Case Report.Cureus · 2024Article
- Article
- β-Catenin-activated inflammatory hepatocellular adenoma with pigmentation and atypical features: a case report.Clinical journal of gastroenterology · 2023Article
- Focal Liver Lesions other than Hepatocellular Carcinoma in Cirrhosis: Diagnostic Challenges.Journal of translational internal medicine · 2022Article
- Benign liver tumours: understanding molecular physiology to adapt clinical management.Nature reviews. Gastroenterology & hepatology · 2022Review
- Etiology, Pathogenesis, Diagnosis, and Practical Implications of Hepatocellular Neoplasms.Cancers · 2022Review
- Hepatocellular adenoma: Where are we now?World journal of gastroenterology · 2022Article
- Autofluorescence imaging within the liver: a promising tool for the detection and characterization of primary liver tumors.European radiology · 2022Article
- JAK/STAT of all trades: linking inflammation with cancer development, tumor progression and therapy resistance.Carcinogenesis · 2021Article
- Focal nodular hyperplasia associated with a giant hepatocellular adenoma: A case report and review of literature.World journal of hepatology · 2021Article
- Hepatocellular adenoma in men: A nationwide assessment of pathology and correlation with clinical course.Liver international : official journal of the International Association for the Study of the Liver · 2021Article
- Hepatic nodules with arterial phase hyperenhancement and washout on enhanced computed tomography/magnetic resonance imaging: how to avoid pitfalls.Abdominal radiology (New York) · 2020Review
- Review
- Hepatocellular nodules in vascular liver diseases.Virchows Archiv : an international journal of pathology · 2018Review
- CT-MRI LI-RADS v2017: A Comprehensive Guide for Beginners.Journal of clinical and translational hepatology · 2018Review
- Hepatocellular carcinoma: a review of diagnostic challenges for the pathologist.Journal of hepatocellular carcinoma · 2018Review
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular adenoma is considered to occur exclusively in non-fibrotic livers. It is a heterogeneous entity and a molecular classification is now widely accepted. The most frequent hepatocellular adenoma subtype, namely inflammatory adenoma, harbor somatic activating mutations of genes involved in the interleukin-6 pathway that lead to high C-reactive protein and serum amyloid A expression. The aim of our study was to investigate a series of benign hepatocellular neoplasms developed on cirrhotic livers and characterized by an unequivocal histological diagnosis. We performed a clinical, pathological, and molecular study of 10 benign hepatocellular neoplasms developed in three patients with cirrhosis. Markers allowing hepatocellular adenoma classification were assessed by quantitative real-time PCR and immunohistochemistry. Samples were sequenced for CTNNB1, HNF1A, IL6ST, GNAS, STAT3, and TERT (promoter) mutations. A control series of 32 classical macronodules developed in cirrhosis related to various etiologies was screened by immunohistochemistry and gene sequencing. The three patients had cirrhosis related to metabolic syndrome and/or alcohol intake; two had a single tumor, while the third developed more than 30 lesions. Microscopic examination showed well-differentiated neoplasms sharing features with inflammatory adenoma including inflammatory infiltrates, sinusoidal dilatation, and dystrophic vessels. Sequencing revealed classical hotspot somatic mutations (IL6ST, n=8; STAT3, n=1; and GNAS, n=1) known to be responsible for IL-6/JAK/STAT pathway activation. Two classical high-grade macronodules demonstrated high serum amyloid A and/or C-reactive protein expression, without gene mutations. Altogether, our findings support the existence of rare inflammatory adenoma developed in cirrhosis.
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