ArticleeLife2015
Retroactive modulation of spike timing-dependent plasticity by dopamine.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed.
- Instructive signals drive learning through behavioral timescale synaptic plasticity in the hippocampus and beyond.Current research in neurobiology · 2026Article
- Reward-tethered place cells support flexible magnitude coding and remapping in the hippocampus.bioRxiv : the preprint server for biology · 2026Article
- Article
- VTA-forebrain connectivity moderates adaptive behavior.Brain structure & function · 2026Review
- A biologically plausible decision-making model based on interacting neural populations.PloS one · 2026Article
- Review
- Psychedelics Reverse the Polarity of Long-Term Synaptic Plasticity in Cortical-Projecting Claustrum Neurons.eNeuro · 2025Article
- In silico investigation of the puzzling dopamine effects on excitability and synaptic plasticity in hippocampal CA1 pyramidal neurons.Scientific reports · 2025Article
- Effects of perinatal iron deficiency on spinal dorsal horn circuits.The journal of pain · 2025Article
- Erasing "bad memories": reversing aberrant synaptic plasticity as therapy for neurological and psychiatric disorders.Molecular psychiatry · 2025Review
- Impact of symmetry in local learning rules on predictive neural representations and generalization in spatial navigation.PLoS computational biology · 2025Article
- Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP.eLife · 2025Article
- Possible antidepressant mechanism of acupuncture: targeting neuroplasticity.Frontiers in neuroscience · 2025Review
- Synaptic Interactions Between Serotonergic and Dopaminergic Systems in Parkinson's Disease.Current neuropharmacology · 2025Review
- Resource-dependent heterosynaptic spike-timing-dependent plasticity in recurrent networks with and without synaptic degeneration.Frontiers in computational neuroscience · 2025Article
- Astrocyte D1/D5 Dopamine Receptors Govern Non-Hebbian Long-Term Potentiation at Sensory Synapses onto Lamina I Spinoparabrachial Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Learning to express reward prediction error-like dopaminergic activity requires plastic representations of time.Nature communications · 2024Article
- Ventral tegmental area dopamine projections to the hippocampus trigger long-term potentiation and contextual learning.Nature communications · 2024Article
- Dopamine Pharmacodynamics: New Insights.International journal of molecular sciences · 2024Review
- Dopamine D1-Receptor Organization Contributes to Functional Brain Architecture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Most reinforcement learning models assume that the reward signal arrives after the activity that led to the reward, placing constraints on the possible underlying cellular mechanisms. Here we show that dopamine, a positive reinforcement signal, can retroactively convert hippocampal timing-dependent synaptic depression into potentiation. This effect requires functional NMDA receptors and is mediated in part through the activation of the cAMP/PKA cascade. Collectively, our results support the idea that reward-related signaling can act on a pre-established synaptic eligibility trace, thereby associating specific experiences with behaviorally distant, rewarding outcomes. This finding identifies a biologically plausible mechanism for solving the 'distal reward problem'.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.