Evidence map›Paper›PMID 26516657›Full record

ArticleGut microbes2015

Rate of establishing the gut microbiota in infancy has consequences for future health.

Shaillay Dogra, Olga Sakwinska, Shu-E Soh, Catherine Ngom-Bru, Wolfram M Brück, Bernard Berger, Harald Brüssow, Neerja Karnani, Yung Seng Lee, Fabian Yap and 3 more

Abstract read
In one paragraph

Article in Gut microbes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shaillay Dograa Singapore Institute for Clinical Sciences (SICS); Agency for Science and Technology Research (A*STAR) ; Singapore.
Olga Sakwinskab Nestlé Research Center ; Lausanne , Switzerland.
Shu-E Sohc Department of Pediatrics ; Yong Loo Lin School of Medicine; National University of Singapore ; Singapore.
Catherine Ngom-Brub Nestlé Research Center ; Lausanne , Switzerland.
Wolfram M Brückb Nestlé Research Center ; Lausanne , Switzerland.
Bernard Bergerb Nestlé Research Center ; Lausanne , Switzerland.
Harald Brüssowb Nestlé Research Center ; Lausanne , Switzerland.
Neerja Karnania Singapore Institute for Clinical Sciences (SICS); Agency for Science and Technology Research (A*STAR) ; Singapore.
Yung Seng Leea Singapore Institute for Clinical Sciences (SICS); Agency for Science and Technology Research (A*STAR) ; Singapore.
Fabian Yapd KK Women's and Children's Hospital ; Singapore.
Yap-Seng Chonga Singapore Institute for Clinical Sciences (SICS); Agency for Science and Technology Research (A*STAR) ; Singapore.
Keith M Godfreyf MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre; University of Southampton and University Hospital Southampton NHS Foundation Trust ; Southampton , United Kingdom.
Joanna D Holbrooka Singapore Institute for Clinical Sciences (SICS); Agency for Science and Technology Research (A*STAR) ; Singapore.

Funding

Medical Research Council MC_UP_A620_1017Medical Research Council MC_UU_12011/4
6 · The paper itself

Abstract

The gut of the human neonate is colonized rapidly after birth from an early sparse and highly distinct microbiota to a more adult-like and convergent state, within 1 to 3 years. The progression of colonizing bacterial species is non-random. During the first months of life several shifts commonly occur in the species prevalent in our guts. Although the sequential progression of these species is remarkably consistent across individuals and geographies, there is inter-individual variation in the rate of progression. Our study and others suggest that the rate is influenced by environmental factors, and influences our future health. In this article, we review our recent contribution to cataloging the developing infant gut microbiota alongside other important recent studies. We suggest testable hypotheses that arise from this synthesis.

Indexed as

Gastrointestinal MicrobiomeHealthHumansInfantInfant, NewbornIntestinesTime FactorsadiposityCaesarean sectiondefining/profiling gut microbiomegestational agegut microbiotaharnessing microbial strategies for treatment of human diseaseimmaturityinfancyobesityprematurityvaginal delivery

Identifiers

PMID26516657
PMCPMC4826121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.