Evidence map›Paper›PMID 26516656›Full record

ReviewGut microbes2015

Reporter systems for in vivo tracking of lactic acid bacteria in animal model studies.

Winschau F van Zyl, Shelly M Deane, Leon M T Dicks

Abstract readReview
In one paragraph

Review in Gut microbes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Bioluminescent imaging to investigateInfection and immunity · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. β-Glucan-ProducingFrontiers in microbiology · 2018
    Article
  7. Temperature-Dependent Gene Expression inFrontiers in microbiology · 2018
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Winschau F van Zyla Department of Microbiology ; Stellenbosch University ; Matieland, Stellenbosch , South Africa.
Shelly M Deanea Department of Microbiology ; Stellenbosch University ; Matieland, Stellenbosch , South Africa.
Leon M T Dicksa Department of Microbiology ; Stellenbosch University ; Matieland, Stellenbosch , South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioluminescence (BLI) and fluorescence imaging (FI) allow for non-invasive detection of viable microorganisms from within living tissue and are thus ideally suited for in vivo probiotic studies. Highly sensitive optical imaging techniques detect signals from the excitation of fluorescent proteins, or luciferase-catalyzed oxidation reactions. The excellent relation between microbial numbers and photon emission allow for quantification of tagged bacteria in vivo with extreme accuracy. More information is gained over a shorter period compared to traditional pre-clinical animal studies. The review summarizes the latest advances in in vivo bioluminescence and fluorescence imaging and points out the advantages and limitations of different techniques. The practical application of BLI and FI in the tracking of lactic acid bacteria in animal models is addressed.

Indexed as

Genes, ReporterAnimalsGastrointestinal TractLactobacillalesLuminescent MeasurementsModels, AnimalOptical ImagingProbioticsStaining and Labelinglactic acid bacteriareporter systems

Identifiers

PMID26516656
PMCPMC4826117

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.