Evidence map›Paper›PMID 26516611›Full record

ArticleBrain and behavior2015

Common variants in the ARC gene are not associated with cognitive abilities.

Craig Myrum, Sudheer Giddaluru, Kaya Jacobsen, Thomas Espeseth, Lars Nyberg, Astri J Lundervold, Jan Haavik, Lars-Göran Nilsson, Ivar Reinvang, Vidar M Steen and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. 'Arc'-hitecture of normal cognitive aging.Ageing research reviews · 2022
    Review
  4. Article
  5. Schizophrenia: What's Arc Got to Do with It?Frontiers in behavioral neuroscience · 2017
    Review
  6. Implication of the APP Gene in Intellectual Abilities.Journal of Alzheimer's disease : JAD · 2017
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Craig MyrumDr. Einar Martens Research Group for Biological Psychiatry Center for Medical Genetics and Molecular Medicine Haukeland University Hospital Bergen Norway ; Department of Biomedicine University of Bergen Bergen Norway ; K.G. Jebsen Center for Research on Neuropsychiatric Disorders University of Bergen Bergen Norway.
Sudheer GiddaluruDr. Einar Martens Research Group for Biological Psychiatry Center for Medical Genetics and Molecular Medicine Haukeland University Hospital Bergen Norway ; K.G. Jebsen Center for Psychosis Research and the Norwegian Center for Mental Disorders Research (NORMENT) Department of Clinical Science University of Bergen Bergen Norway.
Kaya JacobsenDepartment of Biomedicine University of Bergen Bergen Norway ; K.G. Jebsen Center for Research on Neuropsychiatric Disorders University of Bergen Bergen Norway.
Thomas EspesethDepartment of Psychology University of Oslo Oslo Norway ; Norwegian Center for Mental Disorders Research (NORMENT) and the KG Jebsen Center for Psychosis Research Division of Mental Health and Addiction Oslo University Hospital Oslo Norway.
Lars NybergUmeå Center for Functional Brain Imaging Umeå University Umeå Sweden.
Astri J LundervoldK.G. Jebsen Center for Research on Neuropsychiatric Disorders University of Bergen Bergen Norway ; Department of Biological and Medical Psychology University of Bergen Bergen Norway.
Jan HaavikDepartment of Biomedicine University of Bergen Bergen Norway ; K.G. Jebsen Center for Research on Neuropsychiatric Disorders University of Bergen Bergen Norway.
Lars-Göran NilssonAging Research Center Karolinska Institutet Stockholm Sweden ; Umeå Center for Functional Brain Imaging Umeå University Umeå Sweden.
Ivar ReinvangDepartment of Psychology University of Oslo Oslo Norway ; Norwegian Center for Mental Disorders Research (NORMENT) and the KG Jebsen Center for Psychosis Research Division of Mental Health and Addiction Oslo University Hospital Oslo Norway.
Vidar M SteenDr. Einar Martens Research Group for Biological Psychiatry Center for Medical Genetics and Molecular Medicine Haukeland University Hospital Bergen Norway ; K.G. Jebsen Center for Psychosis Research and the Norwegian Center for Mental Disorders Research (NORMENT) Department of Clinical Science University of Bergen Bergen Norway.
Stefan JohanssonK.G. Jebsen Center for Research on Neuropsychiatric Disorders University of Bergen Bergen Norway ; Department of Clinical Science University of Bergen Bergen Norway.
Karin WibrandDepartment of Biomedicine University of Bergen Bergen Norway ; K.G. Jebsen Center for Research on Neuropsychiatric Disorders University of Bergen Bergen Norway.
Stephanie Le HellardDr. Einar Martens Research Group for Biological Psychiatry Center for Medical Genetics and Molecular Medicine Haukeland University Hospital Bergen Norway ; K.G. Jebsen Center for Psychosis Research and the Norwegian Center for Mental Disorders Research (NORMENT) Department of Clinical Science University of Bergen Bergen Norway.
Clive R BramhamDepartment of Biomedicine University of Bergen Bergen Norway ; K.G. Jebsen Center for Research on Neuropsychiatric Disorders University of Bergen Bergen Norway.
University of Bergen · NOHaukeland University Hospital · NOUmeå University · SEUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Activity-Regulated Cytoskeleton-associated (ARC) gene encodes a protein that is critical for the consolidation of synaptic plasticity and long-term memory formation. Given ARC's key role in synaptic plasticity, we hypothesized that genetic variations in ARC may contribute to interindividual variability in human cognitive abilities or to attention-deficit hyperactivity disorder (ADHD) susceptibility, where cognitive impairment often accompanies the disorder.

methodsWe tested whether ARC variants are associated with six measures of cognitive functioning in 670 healthy subjects in the Norwegian Cognitive NeuroGenetics (NCNG) by extracting data from its Genome-Wide Association Study (GWAS). In addition, the Swedish Betula sample of 1800 healthy subjects who underwent similar cognitive testing was also tested for association with 19 tag SNPs.

resultsNo ARC variants show association at the study-wide level, but several markers show a trend toward association with human cognitive functions. We also tested for association between ARC SNPs and ADHD in a Norwegian sample of cases and controls, but found no significant associations.

conclusionThis study suggests that common genetic variants located in ARC do not account for variance in human cognitive abilities, though small effects cannot be ruled out.

Indexed as

AdultAgedAttention Deficit Disorder with HyperactivityCognitionCognition DisordersCytoskeletal ProteinsFemaleGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedNerve Tissue ProteinsNeuronal Plasticityactivity regulated cytoskeletal-associated proteinCytoskeletal ProteinsNerve Tissue ProteinsActivity‐regulated cytoskeleton‐associated proteincognitiongeneticsmemorysingle‐nucleotide polymorphismsynaptic plasticity

Identifiers

PMID26516611
PMCPMC4614059
OpenAlexW1902495809

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.