ArticleBritish journal of pain2013
Pharmacogenetics of analgesic drugs.
Article in British journal of pain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03531268 (Prospective Study to Evaluate the Clinical Utility of Perioperative Pharmacogenomic Testing), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Study to Evaluate the Clinical Utility of Perioperative Pharmacogenomic Testing
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pharmacogenomic-guided opioid therapy for pain: a systematic review and meta-analysis of randomised controlled trials.The pharmacogenomics journal · 2025Pooled it
- Pharmacological therapy of neonatal analgosedation: current status, dilemmas, and perspectives.Frontiers in pediatrics · 2026Review
- Effects of pharmacogenetic profiles on pediatric pain relief and adverse events with ibuprofen and oxycodone.Pain reports · 2023Article
- Article
- Non-opioid analgesics for procedural pain in neonates.The Cochrane database of systematic reviews · 2023Review
- Analgesic and Anti-Inflammatory Effects of Hydroalcoholic and Hexane Extracts ofInternational journal of preventive medicine · 2021Article
- Pharmacogenomics of Pain Management: The Impact of Specific Biological Polymorphisms on Drugs and Metabolism.Current oncology reports · 2020Review
- Molecular Basis of Cancer Pain Management: An Updated Review.Medicina (Kaunas, Lithuania) · 2019Review
- Review
- The plus maze and scototaxis test are not valid behavioral assays for anxiety assessment in the South African clawed frog.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2019Article
- Pharmacogenetic Testing in Acute and Chronic Pain: A Preliminary Study.Medicina (Kaunas, Lithuania) · 2019Article
- Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters.Frontiers in pharmacology · 2019Article
- Clinical pharmacology of analgosedatives in neonates: ways to improve their safe and effective use.The Journal of pharmacy and pharmacology · 2017Review
- A fall from grace: exposing the neurotoxicities of morphine.British journal of pain · 2017Article
- Splice variation of the mu-opioid receptor and its effect on the action of opioids.British journal of pain · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined. • Analgesics act in various ways on the peripheral and central pain pathways and are regarded as one of the most valuable but equally dangerous groups of medications. • While pharmacokinetic properties of drugs, metabolism in particular, have been scrutinised by genotype-phenotype correlation studies, the clinical significance of inherited variants in genes governing pharmacodynamics of analgesics remains largely unexplored (apart from the µ-opioid receptor). • Lack of replication of the findings from one study to another makes meaningful personalised analgesic regime still a distant future. • This narrative review will focus on findings related to pharmacogenetics of commonly used analgesic medications and highlight authors' views on future clinical implications of pharmacogenetics in the context of pharmacological treatment of chronic pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.