Evidence map›Paper›PMID 26516421›Full record

ReviewWorld journal of cardiology2015

Role of platelet-rich plasma in ischemic heart disease: An update on the latest evidence.

Eleftherios Spartalis, Periklis Tomos, Demetrios Moris, Antonios Athanasiou, Charalampos Markakis, Michael D Spartalis, Theodore Troupis, Dimitrios Dimitroulis, Despina Perrea

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Autologous platelet-rich plasma for assisted reproduction.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Observational
  3. Article
  4. Application of Autologous Platelet-Rich Plasma-Supplemented Medium PromotesInternational journal of fertility & sterility · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Eleftherios SpartalisEleftherios Spartalis, Periklis Tomos, Demetrios Moris, Antonios Athanasiou, Charalampos Markakis, Dimitrios Dimitroulis, Second Department of Propedeutic Surgery, Athens University Medical School, "Laiko" Hospital, 11527 Athens, Greece.
Periklis TomosEleftherios Spartalis, Periklis Tomos, Demetrios Moris, Antonios Athanasiou, Charalampos Markakis, Dimitrios Dimitroulis, Second Department of Propedeutic Surgery, Athens University Medical School, "Laiko" Hospital, 11527 Athens, Greece.
Demetrios MorisEleftherios Spartalis, Periklis Tomos, Demetrios Moris, Antonios Athanasiou, Charalampos Markakis, Dimitrios Dimitroulis, Second Department of Propedeutic Surgery, Athens University Medical School, "Laiko" Hospital, 11527 Athens, Greece.
Antonios AthanasiouEleftherios Spartalis, Periklis Tomos, Demetrios Moris, Antonios Athanasiou, Charalampos Markakis, Dimitrios Dimitroulis, Second Department of Propedeutic Surgery, Athens University Medical School, "Laiko" Hospital, 11527 Athens, Greece.
Charalampos MarkakisEleftherios Spartalis, Periklis Tomos, Demetrios Moris, Antonios Athanasiou, Charalampos Markakis, Dimitrios Dimitroulis, Second Department of Propedeutic Surgery, Athens University Medical School, "Laiko" Hospital, 11527 Athens, Greece.
Michael D SpartalisEleftherios Spartalis, Periklis Tomos, Demetrios Moris, Antonios Athanasiou, Charalampos Markakis, Dimitrios Dimitroulis, Second Department of Propedeutic Surgery, Athens University Medical School, "Laiko" Hospital, 11527 Athens, Greece.
Theodore TroupisEleftherios Spartalis, Periklis Tomos, Demetrios Moris, Antonios Athanasiou, Charalampos Markakis, Dimitrios Dimitroulis, Second Department of Propedeutic Surgery, Athens University Medical School, "Laiko" Hospital, 11527 Athens, Greece.
Dimitrios DimitroulisEleftherios Spartalis, Periklis Tomos, Demetrios Moris, Antonios Athanasiou, Charalampos Markakis, Dimitrios Dimitroulis, Second Department of Propedeutic Surgery, Athens University Medical School, "Laiko" Hospital, 11527 Athens, Greece.
Despina PerreaEleftherios Spartalis, Periklis Tomos, Demetrios Moris, Antonios Athanasiou, Charalampos Markakis, Dimitrios Dimitroulis, Second Department of Propedeutic Surgery, Athens University Medical School, "Laiko" Hospital, 11527 Athens, Greece.
Athens International Airport · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial infarction is the most common cause of congestive heart failure. Novel strategies such as directly reprogramming cardiac fibroblasts into cardiomyocytes are an exciting area of investigation for repair of injured myocardial tissue. The ultimate goal is to rebuild functional myocardium by transplanting exogenous stem cells or by activating native stem cells to induce endogenous repair. Cell-based myocardial restoration, however, has not penetrated broad clinical practice yet. Platelet-rich plasma, an autologous fractionation of whole blood containing high concentrations of growth factors, has been shown to safely and effectively enhance healing and angiogenesis primarily by reparative cell signaling. In this review, we collected all recent advances in novel therapies as well as experimental evidence demonstrating the role of platelet-rich plasma in ischemic heart disease, focusing on aspects that might be important for future successful clinical application.

Indexed as

Cardiac repairIschemic heart diseaseMyocardial infarctionMyocardial regenerationPlatelet-rich plasma

Identifiers

PMID26516421
PMCPMC4620078
OpenAlexW1843832799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.