Evidence map›Paper›PMID 26516416›Full record

ReviewWorld journal of cardiology2015

Cardioprotection by remote ischemic conditioning: Mechanisms and clinical evidences.

Alberto Aimo, Chiara Borrelli, Alberto Giannoni, Luigi Emilio Pastormerlo, Andrea Barison, Gianluca Mirizzi, Michele Emdin, Claudio Passino

Abstract readReview
In one paragraph

Review in World journal of cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alberto AimoAlberto Aimo, Chiara Borrelli, Michele Emdin, Claudio Passino, Institute of Life Sciences, Scuola Superiore Sant'Anna, 56126 Pisa, Italy.
Chiara BorrelliAlberto Aimo, Chiara Borrelli, Michele Emdin, Claudio Passino, Institute of Life Sciences, Scuola Superiore Sant'Anna, 56126 Pisa, Italy.
Alberto GiannoniAlberto Aimo, Chiara Borrelli, Michele Emdin, Claudio Passino, Institute of Life Sciences, Scuola Superiore Sant'Anna, 56126 Pisa, Italy.
Luigi Emilio PastormerloAlberto Aimo, Chiara Borrelli, Michele Emdin, Claudio Passino, Institute of Life Sciences, Scuola Superiore Sant'Anna, 56126 Pisa, Italy.
Andrea BarisonAlberto Aimo, Chiara Borrelli, Michele Emdin, Claudio Passino, Institute of Life Sciences, Scuola Superiore Sant'Anna, 56126 Pisa, Italy.
Gianluca MirizziAlberto Aimo, Chiara Borrelli, Michele Emdin, Claudio Passino, Institute of Life Sciences, Scuola Superiore Sant'Anna, 56126 Pisa, Italy.
Michele EmdinAlberto Aimo, Chiara Borrelli, Michele Emdin, Claudio Passino, Institute of Life Sciences, Scuola Superiore Sant'Anna, 56126 Pisa, Italy.
Claudio PassinoAlberto Aimo, Chiara Borrelli, Michele Emdin, Claudio Passino, Institute of Life Sciences, Scuola Superiore Sant'Anna, 56126 Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In remote ischemic conditioning (RIC), several cycles of ischemia and reperfusion render distant organ and tissues more resistant to the ischemia-reperfusion injury. The intermittent ischemia can be applied before the ischemic insult in the target site (remote ischemic preconditioning), during the ischemic insult (remote ischemic perconditioning) or at the onset of reperfusion (remote ischemic postconditioning). The mechanisms of RIC have not been completely defined yet; however, these mechanisms must be represented by the release of humoral mediators and/or the activation of a neural reflex. RIC has been discovered in the heart, and has been arising great enthusiasm in the cardiovascular field. Its efficacy has been evaluated in many clinical trials, which provided controversial results. Our incomplete comprehension of the mechanisms underlying the RIC could be impairing the design of clinical trials and the interpretation of their results. In the present review we summarize current knowledge about RIC pathophysiology and the data about its cardioprotective efficacy.

Indexed as

AtherosclerosisCardiac surgeryIschemic heart diseasePercutaneous coronary interventionRemote ischemic conditioning

Identifiers

PMID26516416
PMCPMC4620073

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.