Evidence map›Paper›PMID 26516415›Full record

ReviewWorld journal of cardiology2015

Lipoprotein-associated phospholipase A2 prognostic role in atherosclerotic complications.

Giuseppe Maiolino, Valeria Bisogni, Giacomo Rossitto, Gian Paolo Rossi

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 65 citations in OpenAlex.

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  16. Inflammation and cardiovascular disease: From mechanisms to therapeutics.American journal of preventive cardiology · 2020
    Review
  17. Review
  18. Article
  19. Review
  20. Elevated Lipoprotein-Associated Phospholipase AInternational journal of hypertension · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Giuseppe MaiolinoGiuseppe Maiolino, Valeria Bisogni, Giacomo Rossitto, Gian Paolo Rossi, Department of Medicine - DIMED, Hypertension Clinic, University of Padua, 35128 Padova, Italy.
Valeria BisogniGiuseppe Maiolino, Valeria Bisogni, Giacomo Rossitto, Gian Paolo Rossi, Department of Medicine - DIMED, Hypertension Clinic, University of Padua, 35128 Padova, Italy.
Giacomo RossittoGiuseppe Maiolino, Valeria Bisogni, Giacomo Rossitto, Gian Paolo Rossi, Department of Medicine - DIMED, Hypertension Clinic, University of Padua, 35128 Padova, Italy.
Gian Paolo RossiGiuseppe Maiolino, Valeria Bisogni, Giacomo Rossitto, Gian Paolo Rossi, Department of Medicine - DIMED, Hypertension Clinic, University of Padua, 35128 Padova, Italy.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis manifests itself clinically at advanced stages when plaques undergo hemorrhage and/or rupture with superimposed thrombosis, thus abruptly stopping blood supply. Identification of markers of plaque destabilization at a pre-clinical stage is, therefore, a major goal of cardiovascular research. Promising results along this line were provided by studies investigating the lipoprotein-associated phospholipase A2 (Lp-PLA2), a member of phospholipase A2 proteins family that plays a key role in the metabolism of pro-inflammatory phospholipids, as oxidized low-density lipoproteins, and in the generation of pro-atherogenic metabolites, including lysophosphatidylcholine and oxidized free fatty acids. We herein review the experimental and clinical studies supporting use of Lp-PLA2 activity for predicting cardiovascular events. To his end we considered not only Lp-PLA2 activity and mass, but also Lp-PLA2 gene variations and their association with incident coronary artery disease, stroke, and cardiovascular mortality. Based on these evidences the major scientific societies have included in their guidelines the measurement of Lp-PLA2 activity among the biomarkers that are useful in risk stratification of adult asymptomatic patients at intermediate cardiovascular risk. The results of two recently published major clinical trials with the Lp-PLA2 inhibitor darapladib, which seem to challenge the pathogenic role of Lp-PLA2, will also be discussed.

Indexed as

AtherosclerosisCoronary artery diseaseLipoprotein-associated phospholipase A2Myocardial infarctionPrognosis

Identifiers

PMID26516415
PMCPMC4620072
OpenAlexW2338736591

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.