ArticleInternational journal of medical sciences2015
Lithium Chloride Promotes Apoptosis in Human Leukemia NB4 Cells by Inhibiting Glycogen Synthase Kinase-3 Beta.
Article in International journal of medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Lithium Chloride-Induced Nuclear Envelope Remodeling in 3D Endometrial Cancer Spheroids.International journal of molecular sciences · 2026Article
- Laser-induced breakdown spectroscopy for lithium-mediated cancer cell detection and ablation.Lasers in medical science · 2025Article
- Microvesicle inhibition enhances the therapeutic effects of ATRA in acute promyelocytic leukemia cells via changes in miRNAs: the promising antileukemic potential of imipramine.Clinical and experimental medicine · 2025Article
- Lithium Induces Oxidative Stress, Apoptotic Cell Death, and G2/M Phase Cell Cycle Arrest in A549 Lung Cancer Cells.Molecules (Basel, Switzerland) · 2025Article
- Transcriptome Analysis Reveals Mycelial and Fruiting Responses to Lithium Chloride inJournal of fungi (Basel, Switzerland) · 2024Article
- Lithium chloride induces apoptosis by activating endoplasmic reticulum stress in pancreatic cancer.Translational oncology · 2023Article
- Lithium: A Promising Anticancer Agent.Life (Basel, Switzerland) · 2023Review
- Lithium in Cancer Therapy: Friend or Foe?Cancers · 2023Review
- Targeting CaN/NFAT in Alzheimer's brain degeneration.Frontiers in immunology · 2023Review
- Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine.Journal of functional biomaterials · 2022Review
- Autophagy modulation as a potential targeted cancer therapy: From drug repurposing to new drug development.The Kaohsiung journal of medical sciences · 2021Review
- LiCl induces apoptosis via CHOP/NOXA/Mcl-1 axis in human choroidal melanoma cells.Cancer cell international · 2021Article
- Inhibition of Glycogen Synthase Kinase 3β Increases the Proportion and Suppressive Function of CD19Frontiers in immunology · 2020Article
- Effects of lithium on the secretory production of recombinant antibody from insect cells.In vitro cellular & developmental biology. Animal · 2019Article
- Lithium chloride inhibits cell survival, overcomes drug resistance, and triggers apoptosis in multiple myeloma via activation of the Wnt/β-catenin pathway.American journal of translational research · 2018Article
- Shikonin suppresses proliferation and induces apoptosis in human leukemia NB4 cells through modulation of MAPKs and c‑Myc.Molecular medicine reports · 2017Article
- The Influence of Lithium and/or Selenium Treatment on Homeostasis of Chosen Bioelements in Rats.Biological trace element research · 2017Article
- Homeostasis of chosen bioelements in organs of rats receiving lithium and/or selenium.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2016Article
- Six2 Is a Coordinator of LiCl-Induced Cell Proliferation and Apoptosis.International journal of molecular sciences · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML). With the application of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), APL becomes one of best prognosis of leukemia. However, ATRA and ATO are not effective against all APLs. Therefore, a new strategy for APL treatment is necessary. Here, we investigated whether lithium chloride (LiCl), a drug used for the treatment of mental illness, could promote apoptosis in human leukemia NB4 cells. We observed that treatment with LiCl significantly accelerated apoptosis in NB4 cells and led to cell cycle arrest at G2/M phase. Moreover, LiCl significantly increased the level of Ser9-phosphorylated glycogen synthase kinase 3β(p-GSK-3β), and decreased the level of Akt1 protein in a dose-dependent manner. In addition, LiCl inhibition of c-Myc also enhanced cell death with a concomitant increase in β-catnin. Taken together, these findings demonstrated that LiCl promoted apoptosis in NB4 cells through the Akt signaling pathway and that G2/M phase arrest was induced by increase of p-GSK-3β(S9).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.