Evidence map›Paper›PMID 26516291›Full record

ArticleTetrahedron letters2015

A Practical, Multi-gram Synthesis of (±)-Herbindole A, (±)-Herbindole B, and (±)-Herbindole C from a Common Intermediate via 6,7-Indole Aryne Cycloaddition and Pd(0)-Catalyzed Cross-Coupling Reactions.

Nalin Chandrasoma, Sivadarshini Pathmanathan, Keith R Buszek

Abstract read
In one paragraph

Article in Tetrahedron letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nalin ChandrasomaDepartment of Chemistry, University of Missouri, 205 Kenneth A. Spencer Chemical Laboratories, 5100 Rockhill Road, Kansas City, MO 64110.
Sivadarshini PathmanathanCenter of Excellence in Chemical Methodologies and Library Development (KU-CMLD), University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047.
Keith R BuszekDepartment of Chemistry, University of Missouri, 205 Kenneth A. Spencer Chemical Laboratories, 5100 Rockhill Road, Kansas City, MO 64110 ; Center of Excellence in Chemical Methodologies and Library Development (KU-CMLD), University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047.

Funding

Phase trafficking in combinatorial chemistry: ROM polymerizationP50GM069663 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI AUBE, JEFFREY · 2003 to 2012
$18.9M
Intramolecular Aryne Cycloadditions and RearrangementsR01GM069711 · NIGMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI BUSZEK, KEITH R. · 2004 to 2008
$1.2M
NIGMS NIH HHS P50 GM069663NIGMS NIH HHS R01 GM069711
6 · The paper itself

Abstract

A practical, multi-gram 10-step synthesis of racemic herbindole A, B, and C from a common intermediate is described. The key step features a remarkably regioselective C-7 metal-halogen exchange and elimination from a Bartoli-generated

Indexed as

aryneBartolicross-couplingcycloadditionherbindolehetaryneindoleindolyneNegishitrikentrin

Identifiers

PMID26516291
PMCPMC4620576

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.