Evidence map›Paper›PMID 26516195›Full record

ReviewEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery2016

Immunotherapy for non-small cell lung cancer: current concepts and clinical trials.

Marissa Mayor, Neng Yang, Daniel Sterman, David R Jones, Prasad S Adusumilli

Abstract readReview
In one paragraph

Review in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. RNA in Cancer Immunotherapy: Unlocking the Potential of the Immune System.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Review
  7. Observational
  8. Article
  9. Review
  10. Review
  11. Article
  12. Immunotherapy in anaplastic thyroid cancer.American journal of translational research · 2020
    Article
  13. PD-L1/PD-1 Axis in Glioblastoma Multiforme.International journal of molecular sciences · 2019
    Review
  14. Article
  15. Adoptive cellular therapies: the current landscape.Virchows Archiv : an international journal of pathology · 2019
    Review
  16. Monoclonal antibodies in cancer immunotherapy.Molecular biology reports · 2018
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marissa MayorThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Neng YangThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Daniel StermanDivision of Pulmonary and Critical Care Medicine, Department of Medicine, New York University, New York, NY, USA.
David R JonesThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Prasad S AdusumilliThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA adusumip@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Tumor Evolution and Changes in MetabolismP50CA086438 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI RIVIERI, ISABELLE · 2000 to 2015
$29.9M
Training and Career Development and Education CoreU54CA137788 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Daniel Alan Heller · 2008 to 2026
$28.1M
SURGICAL ONCOLOGY RESEARCH TRAINING PROGRAMT32CA009501 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Babak J Mehrara · 1985 to 2026
$7.7M
Epigenetic and post-translational regulation of the metastasis suppressor BRMS1R01CA136705 · NCI · UNIVERSITY OF VIRGINIA · PI JONES, DAVID R · 2009 to 2013
$1.5M
Validation of a risk model for stage I lung adenocarcinomaR21CA164568 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ADUSUMILLI, PRASAD S., PATNAIK, SANTOSH KUMAR · 2012 to 2013
$432k
Mesothelin as a biomarker for clinical management of esophageal adenocarcinomaR21CA164585 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ADUSUMILLI, PRASAD S., RIZK, NABIL · 2012 to 2013
$426k
NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA086438NCI NIH HHS R01 CA136705NCI NIH HHS R21 CA164568NCI NIH HHS R21 CA164585NCI NIH HHS T32 CA009501NCI NIH HHS U54 CA137788
6 · The paper itself

Abstract

Recent successes in immunotherapeutic strategies are being investigated to combat cancers that have less than ideal responses to standard of care treatment, such as non-small-cell lung cancer. In this paper, we summarize concepts and the current status of immunotherapy for non-small cell lung cancer, including salient features of the major categories of immunotherapy-monoclonal antibody therapy, immune checkpoint blockade, immunotoxins, anticancer vaccines, and adoptive cell therapy.

Indexed as

ImmunotherapyAnimalsAntibodies, MonoclonalCarcinoma, Non-Small-Cell LungClinical Trials as TopicGenetic EngineeringHumansLung NeoplasmsMiceAntibodies, MonoclonalAdoptive cell therapyAntibody therapyChimeric antigen receptorLung cancerPD-1/PD-L1 blockade

Identifiers

PMID26516195
PMCPMC4851162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.