ArticleThe Journal of infectious diseases2016
Impact of Statins on Influenza Vaccine Effectiveness Against Medically Attended Acute Respiratory Illness.
Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Body composition measurement and diabetes - A new perspective on development of antibodies after SARS-CoV-2 booster vaccination.Journal of diabetes and metabolic disorders · 2025Article
- Polypharmacy and Antibody Response to SARS-CoV-2 Vaccination in Residents of Long-Term Care Facilities: The GeroCovid Vax Study.Drugs & aging · 2023Article
- Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- SREBP signaling is essential for effective B cell responses.Nature immunology · 2023Article
- Modulating cholesterol-rich lipid rafts to disrupt influenza A virus infection.Frontiers in immunology · 2022Review
- The effect of statins on the prevalence and mortality of influenza virus infection: a systematic review and meta-analysis.Archives of medical science : AMS · 2022Review
- Epigenetic susceptibility to severe respiratory viral infections and its therapeutic implications: a narrative review.British journal of anaesthesia · 2020Review
- Statin Use and Influenza Vaccine Effectiveness in Persons >65 Years of Age, Taiwan.Emerging infectious diseases · 2020Article
- Factors Influencing Persistence of Diphtheria Immunity and Immune Response to a Booster Dose in Healthy Slovak Adults.Vaccines · 2019Article
- Influenza Vaccine Effectiveness and Statin Use Among Adults in the United States, 2011-2017.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Observational
- Apical Trafficking Pathways of Influenza A Virus HA and NA via Rab17- and Rab23-Positive Compartments.Frontiers in microbiology · 2019Article
- The Damage-Response Framework as a Tool for the Physician-Scientist to Understand the Pathogenesis of Infectious Diseases.The Journal of infectious diseases · 2018Article
- Immune History and Influenza Vaccine Effectiveness.Vaccines · 2018Review
- Article
- Report on WHO meeting on immunization in older adults: Geneva, Switzerland, 22-23 March 2017.Vaccine · 2018Article
- Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging.NPJ aging and mechanisms of disease · 2018Article
- Article
- Immune response to influenza vaccination in the elderly is altered by chronic medication use.Immunity & ageing : I & A · 2018Article
- Skin immunization by microneedle patch overcomes statin-induced suppression of immune responses to influenza vaccine.Scientific reports · 2017Article
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6 authors.
Funding
Abstract
backgroundStatins have antiinflammatory effects that may impact vaccine-induced immune responses. We investigated the impact of statin therapy on influenza vaccine effectiveness (VE) against medically attended acute respiratory illness (MAARI).
methodsWe conducted a retrospective cohort study over nine influenza seasons using research databases of a large managed care organization in the United States. Influenza vaccination and statin prescription statuses of cohort members and MAARI cases were ascertained on a per-season basis. Incidence rate ratios (IRRs) of MAARI were estimated using Poisson regression and stratified by statin use. Using a ratio of ratios approach, we compared IRRs from periods during to IRRs from periods before influenza circulation and then used relative IRRs to compute VE.
resultsAfter adjustment for multiple prespecified covariates, the influenza VE against MAARI was lower among statin users than nonusers during periods of local (14.1% vs 22.9%; mean difference, 11.4%; 95% confidence interval [CI], -1.7% to 26.1%) and widespread (12.6% vs 26.2%; mean difference, 18.4%; 95% CI, 2.9%-36.2%) influenza circulation.
conclusionsIn this study, statin therapy was associated with reduced influenza VE against MAARI. Since many cases of MAARI are not caused by influenza, studies of the impact of statins on influenza VE against laboratory-confirmed influenza are needed.
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