ArticleReproductive sciences (Thousand Oaks, Calif.)2016
Endometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- The miRNA Mirage: How Close Are We to Finding a Non-Invasive Diagnostic Biomarker in Endometriosis? A Systematic Review.International journal of molecular sciences · 2018Pooled it
- Bushen Huoxue decoction improves the reproduction of endometriosis-associated infertility by regulating Homeobox A10 and αlpha(v)beta(3) integrin expression.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024Article
- Digestive system deep infiltrating endometriosis: What do we know.Journal of cellular and molecular medicine · 2023Review
- An Appraisal of the Tissue Injury and Repair (TIAR) Theory on the Pathogenesis of Endometriosis and Adenomyosis.Biomolecules · 2023Review
- From Retrograde Menstruation to Endometrial Determinism and a Brave New World of "Root Treatment" of Endometriosis: Destiny or a Fanciful Utopia?Biomolecules · 2023Review
- Identification of molecular subtypes and immune infiltration in endometriosis: a novel bioinformatics analysis andFrontiers in immunology · 2023Article
- miR-96-5p regulated TGF-β/SMAD signaling pathway and suppressed endometrial cell viability and migration via targeting TGFBR1.Cell cycle (Georgetown, Tex.) · 2020Article
- Dose-Dependent Decreased Fertility in Response to the Burden of Endometriosis in a Murine Model.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Evaluation of miR-135a/b expression in endometriosis lesions.Biomedical reports · 2019Article
- Endometrial miR-543 Is Downregulated During the Implantation Window in Women With Endometriosis-Related Infertility.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- MicroRNAs in endometriosis: biological function and emerging biomarker candidates†.Biology of reproduction · 2019Review
- Increased circulating miR-370-3p regulates steroidogenic factor 1 in endometriosis.American journal of physiology. Endocrinology and metabolism · 2019Article
- G-Protein-Coupled Receptor CXCR7 Is Overexpressed in Human and Murine Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2018Article
- Overexpression of microRNA-542-3p attenuates the differentiating capacity of endometriotic stromal cells.Reproductive medicine and biology · 2017Article
- Progesterone Resistance in Endometriosis Is Modulated by the Altered Expression of MicroRNA-29c and FKBP4.The Journal of clinical endocrinology and metabolism · 2017Article
- Low Body Mass Index in Endometriosis Is Promoted by Hepatic Metabolic Gene Dysregulation in Mice.Biology of reproduction · 2016Article
- Aberrant Endometrial DNA Methylome and Associated Gene Expression in Women with Endometriosis.Biology of reproduction · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The mechanisms that lead to the altered uterine gene expression in women with endometriosis are poorly understood. Are these changes in gene expression mediated by proximity to endometriotic lesions or is endometriosis a systemic disease where the effect is independent of proximity to the uterus? To answer this question, we created endometriosis in a murine model either in the peritoneal cavity (proximal) or at a subcutaneous remote site (distal). The expression of several genes that are involved in endometrial receptivity (homeobox A10 [Hoxa10], homeobox A11 [Hoxa11], insulin-like growth factor binding protein 1 [Igfbp1], Kruppel-like factor 9 [Klf9], and progesterone receptor [Pgr]) was measured in the eutopic endometrium of mice transplanted with either proximal or distal endometriosis lesions. Decreased expression of Hoxa10, Igfbp1, Klf9, and total Pgr genes was observed in the eutopic endometrium of mice with peritoneal endometriosis. In the mice with distal lesions, overall expression of these genes was not as severely affected, however, Igfbp1 expression was similarly decreased and the effect on Pgr was more pronounced. Endometriosis does have a systemic effect that varies with distance to the end organ. However, even remote disease selectively and profoundly alters the expression of genes such as Pgr. This is the first controlled experiment demonstrating that endometriosis is not simply a local peritoneal disease. Selective alteration of genes critical for endometrial receptivity and endometriosis propagation may be systemic. Similarly, systemic effects of endometriosis on other organs may also be responsible for the widespread manifestations of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.