ReviewSeminars in perinatology2015
Genes and environment in neonatal intraventricular hemorrhage.
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Review in Seminars in perinatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
8.0field-weighted citation impact, top 3% of its field
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Intracranial Hemorrhage and 2-Year Neurodevelopmental Outcomes in Infants Born Extremely Preterm.The Journal of pediatrics · 2021Trial
- Poor Correlation Between Inflammatory and Brain Injury Biomarkers After Neonatal Intraventricular Hemorrhage: A Pilot Study.World neurosurgery · 2025Article
- Advances in Genetic Testing of Neurologically Abnormal Neonates in the Neonatal Intensive Care Unit.Clinics in perinatology · 2025Review
- Intraventricular haemorrhage in premature infants: the role of immature neuronal salt and water transport.Brain : a journal of neurology · 2024Article
- Review
- Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- High Prevalence of Collagenopathies in Preterm- and Term-Born Children With Periventricular Venous Hemorrhagic Infarction.Journal of child neurology · 2023Article
- THYROID DYSFUNCTION IN PREGNANCY: COMPARISON OF OUTCOMES IN INFANTS.Acta clinica Croatica · 2022Article
- Placental pathology and intraventricular hemorrhage in preterm and small for gestational age infants.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Elevated supine midline head position for prevention of intraventricular hemorrhage in VLBW and ELBW infants: a retrospective multicenter study.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- "The First Thousand Days" Define a Fetal/Neonatal Neurology Program.Frontiers in pediatrics · 2021Review
- Role of Fibronectin-1 polymorphism genes with the pathogenesis of intraventricular hemorrhage in preterm infants.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Intraventricular Hemorrhage in Very Preterm Infants: A Comprehensive Review.Journal of clinical medicine · 2020Review
- Placental Pathology Findings and the Risk of Intraventricular and Cerebellar Hemorrhage in Preterm Neonates.Frontiers in neurology · 2020Article
- Pilot study to establish a prospective neonatal cohort: Study of Preterm Infants and Neurodevelopmental Genes (SPRING).BMJ paediatrics open · 2020Article
- Genetic variants associated with patent ductus arteriosus in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Lack of relationship between cord blood erythropoietin and intraventricular hemorrhage in premature neonates: a controversial result.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Successful implementation of an intracranial hemorrhage (ICH) bundle in reducing severe ICH: a quality improvement project.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome 8.Pediatric research · 2018Article
- Maternal, fetal and perinatal factors associated with necrotizing enterocolitis in Sweden. A national case-control study.PloS one · 2018Article
Corrections and comments
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Authors and funding
14 authors at 10 institutions in 3 countries.
Laura R MentDepartment of Pediatrics and Neurology, Yale University School of Medicine, 333 Cedar St, P.O. Box 208064, New Haven, CT 06520-8064. Electronic address: laura.ment@yale.edu.
Ulrika ÅdénDepartment of Women and Child health, Karolinska Institutet, Stockholm, Sweden.
Charles R BauerDepartment of Pediatrics, University of Miami-Leonard M. Miller School of Medicine, Miami, Florida.
Henrietta S BadaUniversity of Kentucky, Lexington, KY.
Waldemar A CarloDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Jeffrey R KaiserDepartment of Pediatrics, University of Arkansas, Little Rock, AR.
Aiping LinDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT.
Charles Michael CottenDepartment of Pediatrics, Duke University, Durham, NC.
Jeffrey MurrayDepartment of Pediatrics, Anatomy and Cell Biology, Biology, Epidemiology, Preventive Medicine, University of Iowa, Iowa City, IA.
Grier PageRTI International, Atlanta, GA.
Mikko HallmanDepartment of Pediatrics and Biocenter, University of Oulu and Oulu University Hospital, Oulu, Finland.
Richard P LiftonDepartment of Genetics, Yale University School of Medicine, New Haven, CT.
Heping ZhangDepartment of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT.
Gene Targets for IVH Study Group and the Neonatal Research Network
Yale University · USDuke University · USKarolinska Institutet · SERTI International · USUniversity of Alabama at Birmingham · USUniversity of Arkansas at Little Rock · USUniversity of Iowa · USUniversity of Kentucky · USUniversity of Miami · USUniversity of Oulu · FI
Funding
Neonatal Research Network Data Coordinating Center (DCC)U10HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 2008 to 2017
$62.3MWORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KOCH, KENNETH L · 1992 to 2010
$35.2MUNIVERSITY OF IOWA CTSA FOR PEDIATRIC RESEARCHUL1RR024979 · NCRR · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2007 to 2011
$31.8MData Ctr for the Cooperative Neonatal Research NetworkU01HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 1998 to 2007
$21.8MVITAMIN K DEFICIENCY IN CHOLESTATIC LIVER DISEASEM01RR008084 · NCRR · CINCINNATI CHILDRENS HOSP MED CTR · PI STRAUSS, ARNOLD W · 1994 to 2009
$20.6MNICHD Cooperative Multicenter Neonatal Research NetworkU10HD021385 · NICHD · WAYNE STATE UNIVERSITY · PI SHANKARAN, SEETHA · 1991 to 2015
$8.7MNICHD Cooperative Multicenter Neonatal Research NetworkU10HD027904 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LAPTOOK, ABBOT R · 1991 to 2015
$8.7MGene Targets for Intraventricular Hemorrhage (IVH)R01NS053865 · NINDS · YALE UNIVERSITY · PI MENT, LAURA R. · 2007 to 2011
$7.9MUSE OF OXANDROLONE TO IMPROVE FUNCTION IN CHRONIC SCIM01RR016587 · NCRR · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALEJANDRO, RODOLFO · 2002 to 2005
$6.8MZIPRASIDONE TREATMENT OF TOURETTE'S SYNDROME IN CHILDRENM01RR006022 · NCRR · YALE UNIVERSITY · PI KESSLER, DAVID A · 1990 to 2003
$6.7MMULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITSU10HD021397 · NICHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DUARA, SHAHNAZ · 1991 to 2006
$6.7MNICHD Cooperative Multicenter Neonatal Research NetworkU10HD034216 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARLO FONT, WALDEMAR A. · 1996 to 2015
$6.4MNCRR NIH HHS M01 RR006022NCRR NIH HHS M01 RR007122NCRR NIH HHS M01 RR008084NCRR NIH HHS M01 RR016587NCRR NIH HHS M01RR16587NCRR NIH HHS M01RR6022NCRR NIH HHS M01RR633NCRR NIH HHS M01RR7122NCRR NIH HHS M01RR750NCRR NIH HHS M01RR8084NCRR NIH HHS M01 RR997NCRR NIH HHS UL1 RR024979NCRR NIH HHS UL1 RR24979NHGRI NIH HHS U01 HG004423NHGRI NIH HHS U01HG4423NICHD NIH HHS R01 HD052953NICHD NIH HHS R01 HD057192NICHD NIH HHS U01 HD036790NICHD NIH HHS U01HD36790NICHD NIH HHS U10 HD021364NICHD NIH HHS U10 HD021373NICHD NIH HHS U10 HD021385NICHD NIH HHS U10 HD021397NICHD NIH HHS U10 HD027851NICHD NIH HHS U10 HD027853NICHD NIH HHS U10 HD027856NICHD NIH HHS U10 HD027871NICHD NIH HHS U10 HD027880NICHD NIH HHS U10 HD027904NICHD NIH HHS U10 HD034216NICHD NIH HHS U10 HD036790NICHD NIH HHS U10 HD040461NICHD NIH HHS U10 HD040492NICHD NIH HHS U10 HD040498NICHD NIH HHS U10 HD040689NICHD NIH HHS U10 HD053109NICHD NIH HHS U10HD21364NICHD NIH HHS U10HD21373NICHD NIH HHS U10HD21385NICHD NIH HHS U10HD21397NICHD NIH HHS U10HD21415NICHD NIH HHS U10HD27851NICHD NIH HHS U10HD27853NICHD NIH HHS U10HD27856NICHD NIH HHS U10HD27871NICHD NIH HHS U10HD27880NICHD NIH HHS U10HD27881NICHD NIH HHS U10HD27904NICHD NIH HHS U10HD34216NICHD NIH HHS U10HD40461NICHD NIH HHS U10HD40492NICHD NIH HHS U10HD40498NICHD NIH HHS U10HD40689NICHD NIH HHS U10HD53109NICHD NIH HHS UG1 HD027880NICHD NIH HHS UG1 HD034216NICHD NIH HHS UG1 HD040492NIDA NIH HHS R01 DA016750NIDA NIH HHS R01 DA016750-09NINDS NIH HHS NS053865NINDS NIH HHS R01 NS053865
Abstract
Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.
Indexed as
Apgar ScoreCerebral VentriclesFemaleGene-Environment InteractionGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyGestational AgeHumansInfantInfant, NewbornInfant, PrematureIntracranial HemorrhagesPregnancyRisk FactorsUnited StatesgenesGWASintraventricular hemorrhageneonatepreterm
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