Evidence map›Paper›PMID 26515929›Full record

ArticlePlacenta2015

Circadian clock-related genetic risk scores and risk of placental abruption.

Chunfang Qiu, Bizu Gelaye, Marie Denis, Mahlet G Tadesse, Miguel Angel Luque Fernandez, Daniel A Enquobahrie, Cande V Ananth, Sixto E Sanchez, Michelle A Williams

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Familial risk of placental abruption.European journal of obstetrics, gynecology, and reproductive biology · 2026
    Article
  4. Association Analysis of SNPs inAnimals : an open access journal from MDPI · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Genomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts.Toxicological sciences : an official journal of the Society of Toxicology · 2019
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Chunfang QiuCenter for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA. Electronic address: Chun-fang.Qiu@Swedish.org.
Bizu GelayeDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Marie DenisUMR Amélioration Génétique et Adaptation des Plantes méditerranéennes et tropicales (AGAP), CIRAD, Montpellier, France.
Mahlet G TadesseDepartment of Mathematics and Statistics, Georgetown University, Washington, DC, USA.
Miguel Angel Luque FernandezDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Daniel A EnquobahrieCenter for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Cande V AnanthDepartment of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Sixto E SanchezSección de Post Grado, Facultad de Medicina Humana, Universidad San Martín de Porres, Lima, Peru; A.C. PROESA, Lima, Peru; Department of Obstetrics and Gynecology, San Marcos University, Lima, Peru.
Michelle A WilliamsDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Harvard University · USCentre de Coopération Internationale en Recherche Agronomique pour le Développement · FRColumbia University Irving Medical Center · USGeorgetown University · USSwedish Medical Center · USUniversidad de San Martín de Porres · PEUniversity of Washington · US

Funding

Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic PlacentalR01HD059827 · NICHD · SWEDISH MEDICAL CENTER, FIRST HILL · PI ANANTH, CANDE V., WILLIAMS, MICHELLE A. · 2010 to 2014
$2.7M
NICHD NIH HHS R01 HD059827NICHD NIH HHS R01-HD059827
6 · The paper itself

Abstract

introductionThe circadian clock plays an important role in several aspects of female reproductive biology. Evidence linking circadian clock-related genes to pregnancy outcomes has been inconsistent. We sought to examine whether variations in single nucleotide polymorphisms (SNPs) of circadian clock genes are associated with PA risk.

methodsMaternal blood samples were collected from 470 PA case and 473 controls. Genotyping was performed using the Illumina Cardio-MetaboChip platform. We examined 119 SNPs in 13 candidate genes known to control circadian rhythms (e.g., CRY2, ARNTL, and RORA). Univariate and penalized logistic regression models were fit to estimate odds ratios (ORs); and the combined effect of multiple SNPs on PA risk was estimated using a weighted genetic risk score (wGRS).

resultsA common SNP in the RORA gene (rs2899663) was associated with a 21% reduced odds of PA (P < 0.05). The odds of PA increased with increasing wGRS (Ptrend < 0.001). The corresponding ORs were 1.00, 1.83, 2.81 and 5.13 across wGRS quartiles. Participants in the highest wGRS quartile had a 5.13-fold (95% confidence interval: 3.21-8.21) higher odds of PA compared to those in the lowest quartile. Although the test for interaction was not significant, the odds of PA was substantially elevated for preeclamptics with the highest wGRS quartile (OR = 14.44, 95%CI: 6.62-31.53) compared to normotensive women in the lowest wGRS quartile. DISCUSSION: Genetic variants in circadian rhythm genes may be associated with PA risk. Larger studies are needed to corroborate these findings and to further elucidate the pathogenesis of this important obstetrical complication.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAbruptio PlacentaeAdultARNTL Transcription FactorsCase-Control StudiesCircadian ClocksCryptochromesFemaleGenotypeHumansNuclear Receptor Subfamily 1, Group F, Member 1PregnancyRisk AssessmentRisk FactorsYoung AdultARNTL Transcription FactorsBMAL1 protein, humanCRY2 protein, humanCryptochromesNuclear Receptor Subfamily 1, Group F, Member 1RORA protein, humanCircadian clockGenetic risk scorePlacental abruptionPregnancySNPs

Identifiers

PMID26515929
PMCPMC5010362
OpenAlexW1802595512

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.